Staff Directory


Solachuddin Jauhari Arief

Academic Qualification

  • Doctor of Philosophy - Doctor of Philosophy, Tokyo Medical and Dental University
  • Ijazah Dokter Gigi - Bachelor Degree, Universitas Indonesia
  • Certificate of completion - Certificate, Saitama University
  • Certificate - Certificate, Tokyo Denki University

Solachuddin Jauhari Arief (Assoc. Prof. Dr.)

Associate Professor
IIUM Kuantan Campus

KULLIYYAH OF DENTISTRY


solachuddin@iium.edu.my
5455


Area of Specialisation


  • Biotechnology ~ Biotechnology ~ Molecular Biology ~ Gene Isolation - Gene Isolation
  • Natural Science ~ Biological Sciences ~ Genetics ~ Other Genetics n.e.c. - Experimental Gene Therapy, Human Experimental Genetics
  • Medical And Health ~ Medical And Health Sciences ~ Dentistry ~ Oral Biology
  • Medical And Health ~ Medical And Health Sciences ~ Clinical Medicine ~ Oncology - Molecular Oncology


Professional Membership


  • 2007 - 2020: Member of Profesional Body / Association: (Member), Japan Cancer Association
  • 2009 - 2020: Member of Profesional Body / Association: (Member), International Dental Association for Dental Research


Teaching Responsibilities


Biochemistry 2014/2015 2020/2021 2018/2019 2013/2014 2019/2020 2012/2013 2017/2018 2015/2016
FAMILY MANAGEMENT 2020/2021
FAMILY MANAGEMENT AND PARENTING 2016/2017 2013/2014 2015/2016 2014/2015 2012/2013 2018/2019 2019/2020 2017/2018
LEADERSHIP AND MANAGEMENT 2017/2018 2016/2017
Microbiology & Immunology 2015/2016 2020/2021 2019/2020 2017/2018 2012/2013 2018/2019 2013/2014
NORMAL STRUCTURE & FUNCTION OF THE HUMAN CELL, TISSUE & BODY SYSTEMS 2019/2020
Oral Biology 2018/2019 2019/2020 2017/2018 2020/2021 2014/2015 2013/2014 2012/2013 2015/2016
PHARMACEUTICAL BIOTECHNOLOGY & BIOPHARMACEUTICAL 2018/2019 2013/2014 2017/2018 2019/2020 2020/2021
PHYSIOLOGY 2019/2020 2018/2019
PRINCIPLES OF CELL AND TISSUE CULTURE 2011/2012 2012/2013
Research Project 2013/2014 2018/2019 2015/2016
STUDY CIRCLE 2 (BROTHER) 2013/2014


Research Projects


Completed
2016 - 2019 Analysis on the Inhibition of Periodontal Pathogens and its Virulence Genes Expression by Virgin Coconut Oil using Quantitative Real-Time Reverse Transcription-PCR(qRT-PCR)
2016 - 2018 Investigation of bioactive compounds from Luvunga scandens and its cytotoxicity against breast cancer cell
2016 - 2019 Molecular mechanisms of anticancer activity of Sarang Semut (Myrmecodia pendans) plant extract on oral squamous cell carcinoma cell line
2015 - 2018 A novel study of virgin coconut oil as an inhibitor against oral microbiata and its remineralisation potential on enamel tooth surface
2015 - 2020 Evaluation of Mechanism of Action of Medium-chain fatty Asid from Virgin Coconut Oil and its Potential Role in Arresting Caries Lesion and Promoting Remineralisation on Dentine and Enamel Tooth Surface
2015 - 2019 Insulin potentiating activity of Coscinium fenestratum (Mengkunyit) in pancreatic beta cells
2015 - 2020 Flax seed extract and its effect on WNT signaling pathway in the osteogenic differentiation potential of stem cells from human exfoliated deciduous teeth (SHED)
2015 - 2019 Tumor suppressor p73?-loaded PLGA/chitosan/Nigella sativa nanoparticles: A novel non-viral gene delivery system for oral squamous cell carcinoma therapy
2014 - 2016 Synthesis, Characterization and Biological Study of Metal Complexes Derived from Thymoquinone
2014 - 2018 In Vitro Anticancer Potentials Of Ethyl P-Methoxycinnamate (EPMC) An Active Ingredient Of Cekur (Kaempferia Galanga) On Human Cancer Cell Lines Differing In P53 Status.
2013 - 2016 Study on Cancer Prevention Strategy by Punica Granatum Extract: The Role of Polyamines in Regulating Cell Cycle and Cell Death in Human Lung Carcinoma A549 Cells
2012 - 2015 The characterization and studies on nti-neoplastic properties of purified bacteriocin from lastic acid bacteris isolated from non broiler chicken
2012 - 2013 Effects of Pluchea Indica on Glucose Uptake and Glucose Transportation (Glut 4) Gene Expression of Adipocyte Cells
2012 - 2015 Synthesis, Characterization and Biological Studies of Dithiocarbamates Derivatives and their Transition Metal Complexes
2012 - 2014 Cellular and Molecular Response of Adipocyte Cells Treated with Mangostins for Glucose Lowering Activity Purpose
2011 - 2013 Identification of Porphyromonas in Subgingival Plaque among Malaysian Patients with Advanced Periodontitis by Targeted Molecular Analysis
2011 - 2014 Proof-of-concepts study of injectable non-viral gene delivery system of DNA-loaded N.Sativa/Chitosan/PLGA nanoparticle to neuro cell lines (Neurobionanoparticles-CR)
2011 - 2013 Study on anticancer activities of b-mangostin extracted from Garcinia malaccensis against human head neck squamous cell carcinoma (HNSCC) cells
2011 - 2015 RU 2011 -Comparation of antibacterial effect between black tea and white tea extract (Camellia sinensis) on streptococcus viridans.
2009 - 2011 Study on Antineoplastic Activity of Thymoquinone, an Active Ingredient of Black seed(Nigella Sativa)againt Oral
2009 - 2010 Cloning of Mutant Breast Cancer Gene
2009 - 2012 Antibacterial activity and cytotoxicity of new modified class lonomer dental cement
2009 - 2012 Study on Antineoplastic Activity of Thymoquinone,an Active Ingredient of Black Seed (Nigella Sativa) against Cervical Cancer Cells
2008 - 2010 Isolation and Cytotoxic Activity Study of Phytochemicals from Calophyllum canum
On-Going
2020 - Present Effect of flaxseed (Linum usitatissimum) extract on oral wound healing demonstrated through fibroblast and osteoblast co-culture: an in-vitro analysis
2019 - Present Development, Characterization and Invitro Study of Flax Seed Oil Ointment for Wound Healing
2019 - Present HIGH-RISK GENOTYPE HPV AND HSV-1 DETECTION ISOLATED FROM BUCCAL SWAB AND UNSTIMULATED SALIVA AND ITS ASSOCIATION WITH ORAL LESIONS AMONG TRANSGENDER PRACTISING HIGH RISK BEHAVIOUR IN MALAYSIA
2019 - Present FRACTURE STRENGTH OF PREMOLARS TEETH TREATED WITH DIFFERENT POST SYSTEMS
2019 - Present PHYSICOCHEMICAL CHARACTERIZATION, IN VITRO AND IN VIVO EVALUATIONS OF CHITOSAN ENRICHED WITH SEA CUCUMBER EXTRACT HYDROGEL AS DENTAL HAEMOSTATIC AGENT.
2019 - Present Healing potential and the predictability of obturation with GuttaFlow Bioseal. An in vitro study.
2017 - Present In Vitro Cytotoxicity Assay, Flow Cytometry, Caspase Assay and Quantitative PCR of GAGs from Stingray
2017 - Present Synthesis, Characterization And Biological Studies Of Substituted Thiadiazine Derivatives And Their Metal Complexes
2015 - Present Upscale Production of the High Antioxidant Jelly Prepared from Baccaurea Angulata Fruit Enrich with Trigona Bee Honey for Head and Neck Patients
2013 - Present Evaluation of the Effect of Ethyl-p-methoxy Cinnamate (EPMC) on PDGF-BB-induced Vascular Smooth Muscle Cells (VSMS) Proliferation and Migration
2013 - Present MOLECULAR AND CELLULAR BIOLOGY OF IIUM Research Unit (i-MOLEC)
2011 - Present RU 2011 -Occupational exposure topathogens within the dental enviroment at the IIUM Kuliyyah of Dentistry.


Award & Recognition


24 Feb, 2020 1st Place Clinical Science (Oral) - Kulliyyah of Dentistry KCDIO
24 Jul, 2019 Murabbi (Teacher) Award 2019 - International Islamic University Malaysia University
26 Apr, 2019 Murabbi (Teacher) Award 2019 Faculty - Kulliyyah of Dentistry KCDIO
13 Feb, 2019 Silver Medal - Others State
05 May, 2018 2nd Place Poster Award - National Dental Student Scientific Conference 2018 National
26 Feb, 2018 1st Place Winner in Poster Presentation - 7th Dental Student Scientific Conference, IIUM KCDIO
26 Feb, 2018 2nd Place Winner in Oral Presentation - 7th Dental Student Scientific Conference IIUM KCDIO
13 May, 2017 ITEX 2019 Gold Medal - Malaysian Invention and Design Society International
02 Sep, 2016 Outstanding Contributor For Journal Articles Indexed in Scopus and ISI - International Islamic University Malaysia University
12 Jun, 2014 Bronze Medal - International Research, Invention and Innovation Exhibition (International IRIIE 2014) University
06 Mar, 2014 Silver Medal - University Malaysia Pahang: Creation Innovation, Technology & Research Exposition 2014 (Citrex 2014) University
20 Feb, 2013 Gold Medal - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE) 2013 University
20 Feb, 2013 Silver Medal - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE) 2013 University
20 Feb, 2013 Bronze Medal - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE) 2013 University
22 Feb, 2012 2 (two) Silver Medals - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE) 2012 University
22 Feb, 2012 Gold Medal - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE) 2012 University
10 Feb, 2011 3 (three) Bronze Medals - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE 2011) University
10 Feb, 2011 Gold Medal - International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIIE 2011) University
16 May, 2010 Bronze Medal - The 21st International Invention, Innovation and Technology Exhibition (ITEX) National
27 Jan, 2010 Silver Medal - The 2010, International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIE 2010) University
10 Jan, 2008 The Best Paper Award - The Ochanomizu Foundation for Medical and Dental Profession, Japan International
31 Aug, 2007 The 19th Japanese Association for Oral Biology Award for Rising Members - Japanese Association for Oral Biology, Japan International
23 Sep, 2006 The Best Poster Presentation Award - Japanese Association for Oral Biology, Japan International
22 Dec, 2005 Post-Doctoral Fellowship Award for Foreign Researcher - Japan Society for the Promotion of Science International


Publications


Article

2017 Proteins are potent biomarkers to detect colon cancer progression. Saudi Journal of Biological Sciences, 24 (6) pp. 1212-1221
2015 Alpha-mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells via PPAR gamma, GLUT4, and leptin expressions. Evidence-Based Complementary and Alternative Medicine, 15 () pp. 1-9
2015 Anti-proliferative activities of purified bacteriocin from enterococcus mundtii strain c4l10 isolated from the caecum of Malaysian non-broiler chicken on cancer cell lines. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (2) pp. 334-337
2015 Antioxidant activity and phenolic profile of various morphological parts of underutilised Baccaurea angulata fruit. Food Chemistry, 172 () pp. 778-787
2015 Biological properties of cucumber (Cucumis sativus L.) extracts = Sifat-sifat biologi ekstrak timun (Cucumis sativus L.) . Malaysian Journal of Analytical Sciences (MJAS), 19 (6) pp. 1218-1222
2015 Commelina nudiflora L. edible weed as a novel source for gold nanoparticles synthesis and studies on different physical–chemical and biological properties. Journal of Industrial and Engineering Chemistry, 27 () pp. 59-67
2015 Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis. Biochemical and Biophysical Research Communications, 468 (1-2) pp. 248-254
2015 Herbal extracts exhibit anti-diabetic activities in 3T3-L1 adipocytes model. Progress in Nutrition, 17 (4) pp. 301-310
2015 Intracellular biosynthesis of Au and Ag nanoparticles using ethanolic extract of Brassica oleracea L. and studies on their physicochemical and biological properties. Journal of Environmental Sciences, 29 () pp. 151-157
2015 Review on in-vitro amebocyte culture–a lesson learned from past . Jurnal Teknologi, 77 (25) pp. 171-176
2015 Review on invitro amebcyte culture – a lesson learned from past. Jurnal Teknologi, 77 (25) pp. 171-176
2014 Anti-proliferative bacteriocins active against MRSA from coagulase negative Ent. mundtii strain C4L10 isolated from non-broiler chicken. Journal of Probiotics & Health, 2 (2) pp. 53
2014 Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines. Chinese Journal of Physiology , 57 (5) pp. 249 -255
2014 Beyond anticoagulant: heparin as a potential anti-cancer agent. Journal of Biochemistry, Microbiology and Biotechnology, 2 (2) pp. 37-43
2014 Dose water extract of cinnamon (cinnamomum zeylanicum) exhibits anti-diabetic properties in cultured 3T3-L1 adipocytes: a concurrent assessment of adipogenesis, lipolysis and glucose uptakes. Journal of Food and Nutrition Research, 2 (11) pp. 764-769
2014 Nutraceuticals as potential therapeutic agents for colon cancer: a review. Acta Pharmaceutica Sinica B, 4 (3) pp. 173-181
2013 Antioxidant and cytotoxic properties of two sea cucumbers, holothuria edulis lesson and stichopus horrens selenka. Acta Biologica Hungarica, 64 (1) pp. 10-20
2013 Changes in the markers of atherosclerosis following administration of Belimbing dayak (Baccaurea angulata) fruit juice in experimental rabbits fed with cholesterol diet. International Journal of Advances in Agricultural & Environmental Engineering (IJAEE), 1 (1) pp. 151-154
2013 In vitro antioxidant properties of underutilized baccaurea angulata fruit. International Journal of Advances in Agricultural & Environmental Engineering (IJAEE), 1 (1) pp. 144-150
2013 Selected herbal extracts improve diabetes associated factors in 3T3-L1 adipocytes. Procedia - Social and Behavioral Sciences, 91 () pp. 357-375
2012 Apoptosis, antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f. Asian Pacific Journal of Tropical Medicine, 5 (2) pp. 136-141
2012 Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage. Biochemical and Biophysical Research Communications, 417 (2) pp. 710-716
2012 Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation. Biochemical and Biophysical Research Communications, 417 (3) pp. 931-937
2012 Study on antidiabetic plants cocktail containing Andrographis paniculata, Cinnamomum burmannii and Tinospora crispa. Malaysian Journal of Pharmaceutical Sciences, 1 (10) pp. 116
2012 The phytochemical content and antimicrobial activities of Malaysian Calophyllum canum (stem bark). Pakistan Journal of Pharmaceutical Sciences, 25 (3) pp. 555-563
2011 Antioxidant and cytotoxic activities of Calophyllum rubiginosum. International Journal of Phytomedicine, 3 (2) pp. 157-163
2011 Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines. Australian Journal of Basic and Applied Sciences, 5 (8) pp. 47-51
2010 Antioxidant activity of leaves of Calophyllum Rubiginosum. American Journal of Applied Sciences , 7 (10) pp. 1305-1309
2010 Mangostins and their bioactivities from garcinia Malaccensis HK.F. Malaysian Journal of Pharmaceutical Sciences, 8 (sup.1) pp. 13
2008 Defect in ser46 phosphorylation of p53 protein: a resistance mechanism against p53 gene transfer in oral squamos cell carcinoma cells. Journal of Oral Biosciences, 50 (2) pp. 98-106
2006 Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells . Oncogene, 25 (8) pp. 1216-1224
2003 E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53. Molecular Cancer Research, 1 (6) pp. 438-444
Conference or Workshop Item

2015 Antibacterial effect of white tea and black tea extracts on Streptococcus mutans and Streptococcus sobrinus. In: 7th National Dental Students' Scientific Conference 2015,
2015 Critical review on invitro amebcyte culture: a lesson learned from past. In: International Conference on Advancement in Science and Technology (iCAST 2015) - ‘Frontiers in Biotechnology’,
2015 Cytotoxic study of Linum usitatissimum and Salvia officinallis extracts on MCF-7 cell line (comparative study) . In: International Conference on Advancement in Science and Technology (iCAST 2015) - ‘Frontiers in Biotechnology’,
2015 Dental bio-aerosol: a potential occupational hazard in dental practice. In: 11th FDI-IDA Continuing Dental Education Padang 2015,
2014 α-Mangostin improves glucose uptake and inhibits adipocytes differentiation in 3T3-L1 cells. In: 5th FIP Pharmaceutical Sciences World Congress (PSWC 2014),
2014 Biological properties of cucumber (Cucumis sativus L.) extracts. In: 27th Regional Symposium of Malaysia Analytical Sciences,
2014 Cytotoxic activity of luvunga scandens plant on human cancer cell lines. In: 1st International Conference on Industrial Pharmacy,
2014 Cytotoxic agents from luvunga scandens human breast adenocarcinoma cell line (MCF-7). In: International Conference on Natural Products 2014,
2014 Highly cytotoxic agents from luvunga scandens against human breast adenocarcinoma Cell Line (MCF7) . In: International Research, Invention and Innovation Exhibition 2014 (IRIIE2014),
2014 Pluchea indica extracts stimulates insulin secretion through enhancement of Irs2 and Glut2 genes expression in RIN-5F pancreatic β-cells . In: (ICNSE) International Congress on Natural Sciences and Engineering and (ICCBES) International Congress on Chemical, Biological and Environmental Sciences,
2014 Potential hypocholesterolemic and health benefitsof Baccaurea angulata fruit in hypercholesterolemic rabbits. In: K.A.H.S. Research Week 2014,
2013 Antiobesity effects of α-mangostin through glut4 and leptin expression together with pparγ activation in adipocytes. In: IIUM Research, Innovation and Invention Exhibition 2010 (IRIIE 2010),
2013 Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage . In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2013,
2013 Effect of Pluchea Indica on glucose consumption of chang liver cells. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013),
2013 Halal issues in the mammalian cell culture for recombinant protein production. In: National Conference on Industry-Academia Joint Initiatives in Biotechnology 2013,
2013 In vitro Antioxidant and Lipid Peroxidation inhibitory properties of Baccaurea angulata fruit extracts. In: 5th Global Summit on Medicinal and Aromatic Plants (GOSMAP-5),
2013 In vivo antioxidant efficacy of Baccaurea angulata fruit extracts . In: 5th Global Summit on Medicinal and Aromatic Plants (GOSMAP-5),
2013 Insulin mimicking activities of Cycloartane Triterpenoid in 3T3-L1 cells. In: IIUM Research, Invention and Innovation Exhibition 2013 (IRIIE 2013),
2013 Microbial contamination of equipment in the dental laboratory. In: 2nd Meeting of the International Association for Dental Research- Asia Pacific Region,
2013 Nitrogen Sulfur Compounds - Cytotoxic study and their potential application. In: IIUM Research, Invention and Innovation Exhibition, IRIIE 2013,
2013 Synthesis and characterization of various type of Azines as potential bioactive agents. In: 2013 2nd International Conference on Environment, Chemistry and Biology (IPCBEE),
2013 Xanthones from Garcinia Malaccencis improve Glut4 aswell as decreased Pparγ activation on adipocytes . In: International Conference on Natural Products 2013,
2012 Cycloartane triterpenoid as an insulin mimicking agent. In: The 24th FAPA Congress 2012,
2012 Mangostins stimulate glucose uptake and inhibit adipocyte differentiation in 3T3-L1 adipocytes. In: The 24th FAPA Congress 2012,
2012 Site-directed mutagenesis for the production of mutant TP53 gene and analysis of its tumor suppressor activity. In: International Conference in Biomedical Science 2012,
2012 Thymoquinone, an active ingredient of Black Seed (Nigela saliva) induces distinct apoptotic pathways in C33A and Siha Cervical Cancer Cell Lines). In: International Conference Research and Application on Traditional Complementary and Alternative Medicine in Health Care (TCAM 2012),
2011 Antidiabetic activities of Cinnamomum zeylanicum and Tinospora crispa on adipocytes . In: International Conference on Natural products (ICNP 2011),
2011 Cell migration for in vitro wound healing evaluation- a pilot study on Channa striata. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011,
2011 Chemical constituents and bioactivities of Garcinia malaccensis Hk.f. In: International Conference on Natural Products,
2011 Effects of spices and herbal extract on Preadipocyte Cell Differentiation:preliminary results. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011,
2011 Potential bioactivities of -mangostin from garcinia malaccensis Hk.f . In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011,
2011 Silencing endogenous mutant P53 Using Sirna Induces P73-Mediated Apoptosis in Human Head And Neck Squamous Cell Carcinoma . In: 25th Scientific Meeting of The Malaysian Society Of Pharmacology And Physiology,
2011 Synergistic anti-cancer effects of recombinant adenoviruses DRIL1 and p53 gene transfer against human lung cancer cells. In: IIUM Research, Invention and Innovation Exhibition IRIIE 2011,
2010 Anti-cancer activities of Thymoquinone, constituents of Nigella sativa against oral cancer cell lines . In: 9th Scientific Meeting of International Association for Dental Reesarch,
2010 Bioactivities of a-mangostin from Garcinia malaccensis Hk.f. In: International Conference on Advancement in Science and Technology (iCAST2010): The Science of Traditional Practices in Health and Disease,
2010 Growth Suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73beta. In: International Conference of Advancement in Science and Technology (IIUM-iCAST 2010),
2010 Growth suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73B. In: 3rd International Conference on Advancement in Science and Technology (iCAST) 2010,
2010 Production of recombinant p53 protein by PCR-based site directed mutagenesis of plasmid DNA. In: The 21st International Invention, Innovation and Technology Exhibition (ITEX),
2010 Production of recombinant protein by gene cloning from mammalian cell culture. In: International Islamic University Malaysia Research, Invention and Innovation Exhibition (IRIE 2010),
2010 Study of antihyperglycaemic properties of selected Malaysian antidiabetic plants in cultured 3T3-L1 cells. In: 3rd International Conference on Advancement in Science and Technology (iCAST) 2010,
Book Section

2012 Therapeutic targeting of p53-mediated apoptosis pathway in head and neck squamous cell carcinomas: current progress and challenges. In: InTech, ISBN: 978-953-307-879-3, pp. 129-144