Fazia Adyani Ahmad Fuad is an Associate Professor at the Department of Chemical Engineering & Sustainability, Faculty of Engineering. Fazia's academic path began with a BSc (Biochemistry), which was obtained from University Kebangsaan Malaysia (UKM) in 2004. She then furthered her studies for a Masters degree at the same institution, specialising in Plant Biotechnology and successfully completed her studies in 2008.
She later pursued her doctoral degree (Structural Biochemistry) at the University of Edinburgh, Scotland, UK. She was awarded her Ph.D in 2012 and served as a lecturer at Institute for Research in Molecular Medicine (INFORMM), Health Campus, University Science Malaysia, before joining IIUM in 2014. Fazia's Ph.D project focused on drug design and discovery analyses on specific protein targets, in collaboration with University Catholique de Louvain, Brussels and National Institutes of Health (NIH), USA. Since then, she has published her work in a number of international conferences and ISI-indexed journals. Currently, Fazia is interested in investigating the potential of specific enzymes that are involved in various metabolic pathways as chemotherapeutic targets for tropical diseases, such as dengue and malaria. Her main interests include a combination of in silico drug design and biochemical analyses on specific protein targets, which allows further understanding of various protein-protein and protein-ligand interactions.

• Natural Science ~ Bioinformatics ~ Structural Bioinformatics ~ Structural Proteomics - Proteomics
• Natural Science ~ Biological Sciences ~ Biochemistry ~ Proteins - Structural Biochemistry & Molecular Biology
• Biotechnology ~ Biotechnology ~ Biopharmacy Biotechnology ~ Drug Discovery - Drug Design & Discovery
• Natural Science ~ Bioinformatics ~ Systems Biology ~ Other Systems Biology n.e.c. - Biology

• 2011 : Member of Profesional Body / Association: (Member), Biochemical Society, UK
• 2015 : Member of Profesional Body / Association: (Member), Royal Society of Chemistry (RSC), UK
• 2018 : Member of Profesional Body / Association: (Member), Bioinformatics and Computational Biology Society Malaysia (MASBIC)
• 2019 : Member of Profesional Body / Association: (Senior Member), Hong Kong Chemical, Biological & Environmental Engineering Society (HKCBEES), Hong Kong
• 2020 : Member of Profesional Body / Association: (Member), Abu Hurairah Animal Society
• 2021 : Member of Profesional Body / Association: (Member), Abu Hurairah Animal Society IIUM
• 2022 : Member of Profesional Body / Association: (Applied fo Membership), Malaysia Society for Engineering & Technology (MySET)
• 2022 : Member of Profesional Body / Association: (Graduate Technologist), Malaysia Board Of Technologists (MBOT)

BIOCHEMISTRY	2022/2023 2021/2022
BIOTECHNOLOGY ENGINEERING LAB III	2023/2024 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019 2017/2018 2016/2017 2015/2016
CELL AND TISSUE ENGINEERING	2015/2016 2014/2015
CHEMICAL ENGINEERING LABORATORY 3	2025/2026 2024/2025
FINAL YEAR PROJECT 1	2025/2026 2024/2025
FINAL YEAR PROJECT 2	2025/2026
FINAL YEAR PROJECT II	2024/2025 2018/2019
INTRODUCTORY MICROBIOLOGY	2022/2023
LIFE SCIENCES FOR CHEMICAL ENGINEERIS	2025/2026 2024/2025 2023/2024 2022/2023
MOLECULAR BIOLOGY AND GENETIC ENGINEERING	2023/2024 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019 2017/2018 2016/2017 2015/2016
MOLECULAR FARMING (BIOMOLECULAR)	2016/2017 2015/2016
PROJECT I	2021/2022 2020/2021 2019/2020 2018/2019
SEMINAR	2015/2016 2014/2015
USRAH IN ACTION 1	2023/2024
USRAH IN ACTION 2	2023/2024

Anticancer Activity Of Ionic Liquid Graviola Fruit (Annona Muricata) Extract On Mcf-7 And Ht29 Cancer Cell Lines Using In Vitro And In Vivo Methods. Ph.D Completed 2020 Co-supervisor

Deciphering The Mechanism Of Chitin As A Potent Inhibitor Of Human Hexokinase 2 For Improved Anti-Dengue Theraputics. Ph.D In Progress Main Supervisor

Exploring The Impact Of Plasmodium Falciparum Kelch 13 Protein Mutations On Artemisinin - Based Antimalarial Drug Interactions : A Computational And Protein Interaction Study. Master Completed 2024 Main Supervisor

Identification Of Potential Inhibitors Of Human Hexokinase Ii For The Development Of Anti-Dengue Therapeutics. Master Completed 2021 Main Supervisor

Virtual Screening And Enzymatic Inhibition Analysis Of Bacterially Expressed Lactate Dehydrogenase From Plasmodium Knowlesi For Antimalarial Drug Development. Master Completed 2021 Main Supervisor

Exploring Chitin-Based Compounds As Inhibitors Of Bacterially-Expressed Human Hexokinase Isoform 2 As Potential Dengue Treatment . Master In Progress Main Supervisor

Structural Ensemble Screening Of Macrocycles For Physicochemical Profiling In Targeted Kinase Inhibition. Master In Progress Co-supervisor

Completed

2018 - 2023	Collagen-Like Protein from Selected Bacteria as Alternative For Non-Halal Collagen
2017 - 2019	Fractionation and partial purification of active compounds from agarwood branch extract responsible for the cytotoxic/anticancer activity
2016 - 2021	Interrogating Novel Compounds for Improved Anti-dengue Therapies via Inhibition of Host's Glycolytic Pathway
2015 - 2019	Identification of Novel Antimalarial Agents for the Treatment of Knowlesi Malaria via in silico Screening and Enzynmatic Inhibition Analysis

On-Going

2023 - Present	Deciphering the Mechanism of Chitin as a Potent Inhibitor of Human Hexokinase Isoform 2 for Improved Anti-Dengue Therapeutics
2022 - Present	Directed Evolution library construction of kinase enzyme for the mediation of phosphorothioate bond formation using Molecular Dynamics and Machine Learning-assisted Fitness Analysis
2022 - Present	Elucidating the Inhibitory Effects of Chitin on Human Hexokinase Isoform 2 as a Lead Compound for Dengue Treatment
2021 - Present	Identification of potential anti-malarial compounds from natural products using virtual screening and in-vitro inhibition studies for the treatment of malaria
2020 - Present	Confirmation, Validation, and Characterization of Antimalarial Drug (Artemisinin) Resistant K13 Selected Genes on Plasmodium Falciparum in Malaysian Isolates
2020 - Present	Investigating the Potential Use of an LED-Photodiode Pair as a Flow Velocimetry Imaging Technique for Non-Invasive Measurement of Peritoneal Dialysis Fluid
2018 - Present	ANAEROBIC CO-DIGESTION OF SEWAGE SLUDGE AND FOOD WASTE FOR BIOGAS PRODUCTION AND MICROBIAL COMMUNITY IDENTIFICATION
2006 - Present	Bio-Process and Molecular Engineering Research Unit (BPMERU)

10 Dec, 2021	Top Researchers with the Highest Number of Joint Publications from 2019-2021 - International Islamic University Malaysia	University
30 Mar, 2021	Main Recipient of Best Journal Award for Science, Technology, and Medicine (International Indexed Journal), MAPIM-KPT Awards Ceremony 2019 - Ministry of Higher Education	National
21 Sep, 2015	The Travel Grant Award - Biochemical Society UK	International

Articles

2025	Evaluating the effects of chitin and Its analogues with improved solubility on human Hexokinase Isoform 2 for Dengue treatment via virtual screening analyses. Molekul, 20 (1) pp. 86-96
2025	Evaluation of culture media and induction conditions as a strategy for optimising soluble human Hexokinase Isoform 2 Expression in Escherichia coli BL21 StarTM (DE3). fazia_adyani@iium.edu.my, 11 (1) pp. 22-38
2024	Evaluation of the binding interactions between Plasmodium falciparum Kelch-13 mutant recombinant proteins with artemisinin. PLOS One, 19 (8) pp. 1-17
2024	In silico studies of the interactions of chitin-based compounds and AeHKT enzyme for the development of dengue larvicides. Semarak International Journal of Petroleum and Chemical, 1 (1) pp. 38-50
2023	Repurposing natural products against Plasmodium Knowlesi lactate dehydrogenase via in Silico approach for antimalarial drug development. Chemical and Natural Resorces Engineering Journal, 7 (2) pp. 78-87
2022	Analogues of Oxamate, Pyruvate, and Lactate as potential inhibitors of Plasmodium Knowlesi lactate Dehydrogenase identified using virtual screening and verified via Inhibition Assays. Processes, 10 (11) pp. 1-8
2022	Evaluating the binding interactions between Artemisinin and Kelch 13 protein mutants via molecular modelling and docking studies. Journal of Advanced Research in Applied Sciences and Engineering Technology, 28 (3) pp. 272-286
2021	Enhanced expression and purification strategy for recombinant bacterially-expressed human hexokinase II. Molekul, 16 (1) pp. 82-91
2021	Purifying and characterizing bacterially expressed soluble Lactate Dehydrogenase from Plasmodium knowlesi for the development of anti-malarial drugs. Molecules, 26 (21) pp. 1-13
2021	Virtual screening for potential inhibitors of human hexokinase II for the development of anti-dengue therapeutics. BioTech, 10 (1) pp. 1-28
2020	Effects of Daidzin and analogue of Ganoderma sinense on bacterially-expressed human hexokinase isoform 2 for anti-dengue drug design. Biological And Natural Resources Engineering Journal, 3 (2) pp. 27-34
2019	Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques. Journal of Ethnopharmacology, 236 () pp. 466-473
2019	Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches. Microorganisms, 7 (9) pp. 1-28
2019	Identifying analogues of 2-deoxyglucose, alpha-d-glucose and beta-d-glucose-6-phosphate as potential inhibitors of human hexokinase ii for the development of anti-dengue therapeutics. Pertanika Journal of Science and Technology, 27 (4) pp. 1625-1647
2019	Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (4) pp. 38-53
2017	Screening potential inhibitors of lactate dehydrogenase from Plasmodium knowlesi via virtual screening approaches. Tropical Biomedicine, 34 (4) pp. 1-14
2016	Inhibitors of leishmania mexicana phosphoglycerate mutase identified by virtual screening and verified by inhibition studies. Sains Malaysiana, 45 (7) pp. 1113-1120
2014	Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states. Biochemical and Biophysical Research Communications, 450 () pp. 936-941
2011	Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo. Metallomics, 3 () pp. 1310-1317
2008	Super binary vector system enhanced transformation frequency and expression level of polyhydroxyvalerate gene in oil palm immature embryo. Asian Journal of Plant Sciences, 7 (6) pp. 526-535

Conference or Workshop Items

2022	The glycolytic pathway is a target for drug discovery against tropical diseases. In: The 4th International Conference on Biosciences & Medical Engineering,
2021	Computational approaches for evaluation of malaria drug resistance in plasmodium species. In: 6th International Conference of Biotechnology Engineering 2021,
2021	Virtual screening and in silico Interactions studies for potential antivirals and diagnostics against the spike protein from the Novel Coronavirus SARS-Cov-2. In: 6th International Conference on Biotechnology Engineering (ICBioE 2021),
2020	Interrogating novel compounds for improved anti-dengue therapies via inhibition of human hexokinase II (HKII). In: Nanotechnology Symposium 2020,
2020	Novel compounds as potential anti-dengue therapies verified via inhibition of human hexokinase isoform II. In: Kulliyyah of Engineering Research, Innovation and Commercialization Exhibition 2020 (KERICE '20),
2019	Elucidating the analogues of 3-bromopyruvate (3-BP) as inhibitors against human hexokinase II for the development of anti-dengue drugs. In: 8th International Molecular Biology And Biotechnology Congress (MOLBIOTECH),
2019	Expression and purification of soluble bacterially-expressed human hexokinase II in E.coli system. In: "9th International Conference on Biomedical Engineering and Technology, ICBET 2019",
2019	In Silico Screening of Inhibitors Against Bacterially Expressed Plasmodium knowlesi Lactate Dehydrogenase Enzyme. In: Kulliiyah of Engineering Research, Innovation, Commercialisation and Exhibition 2019 (KERICE 2019),
2019	Potential inhibitors of Human Hexokinase II for the development of anti-dengue therapeutics identified via in silico approach. In: Kuliyyah of Engineering Research, Innovation and Commercialization Exhibition 2019 (KERICE 2019),
2019	Stimulating scientific minds among early secondary students in Malaysia: a pilot study  using ‘engineering and electronics made fun’ approach. In: 1st International Conference on STEM Education,
2018	Analogues of 2-Deoxyglucose as inhibitor candidates for hexokinase II identified via virtual screening analyses. In: 5th International Conference on Biotechnology Engineering (ICBioE 2018),
2018	Cloning and expression of lactate dehydrogenase from plasmodium knowlesi for anti-malarial drug development. In: Asia Pacific Academic Consortium for Public Health Conference,
2018	Simulation study of bio-methane conversion into hydrogen for generating 500 kw of power. In: 3rd International Conference on Electrical Systems, Technology and Information, ICESTI 2017,
2017	Identifying potential inhibitors of human hexokinase II for the development of anti-dengue therapeutics via virtual screening approaches. In: 4th Asian Regional Conference on Systems Biology,
2016	Cloning and characterisation of Lactate Dehydrogenase Gene from Plasmodium knowlesi in bacterial system. In: Borneo Biotech Symposium,
2016	Potential inhibitors of the glycolytic enzymes from Plasmodium knowlesi identified by virtual screening analysis. In: International Conference of Biotechnology Engineering (ICBioE2016),
2015	Potential novel inhibitors of trypanosomatid phosphoglycerate mutases through ligand-based and structure-based in silico approaches. In: Singapore Health and Biomedical Congress 2015,
2013	Multiple oligomeric and conformational states of trypanosomatid phosphoglycerate mutases. In: 18th Lorne Proteomics Symposium 2013,

Books

2024	Circular bioeconomy: towards a sustainable future. Springer, ISBN: 978-981-97-7009-0

Book Sections

2024	Synthetic biology as a building block for circular Bioeconomy: a case study of Chitin. In: Springer Nature, ISBN: 978-981-97-7009-0, pp. 25-50
2018	Characterization of conformational and oligomeric states of proteins. In: Springer Nature Singapore, ISBN: 978-981-13-2256-3, pp. 167-178
2018	Characterization of conformational and oligomeric states of proteins. In: Springer Nature Singapore, ISBN: 978-981-13-2256-3, pp. 167-178
2018	Secondary metabolite research in Malaysia: current status and future prospects. In: IntechOpen, ISBN: 978-1-78923-643-9, pp. 101-111