Dr How Soon Hin graduated from University of Malaya, Kuala Lumpur in 1996 and obtained his Master in Internal Medicine at the same university in 2002. He is currently working as Professor of Medicine, Kulliyyah of Medicine, International Islamic University and also serves as a consultant general physician and chest physician in Hospital Tengku Ampuan Afzan, Jalan Tanah Putih, 25100, Kuantan, Pahang (HTAA).
He has special interests in EBUS-TBNA, rigid bronchoscopy, metallic and silicone stenting, laser, endobronchial tumour debulking etc. His research interests are in melioidosis and lung cancer and he has published more than 55 papers in both local and international journals, and presented more than 80 abstracts at both local and international scientific meetings.

• Medical And Health ~ Medical And Health Sciences ~ Biomedical Sciences ~ Other Biomedical Sciences n.e.c. - Consultant Physician and Chest Physician

• 2009 - 2011: Member of Profesional Body / Association, Malaysia COPD Clinical Practise Guideline

GENERAL MEDICINE & GENERAL SURGERY

2023/2024

Completed

2021 - 2023	Polymerase Chain Reaction (Pcr) Versus Blood Culture To Detect Burkholderia Pseudomallei Species In High Risk Patients With Suspected Or Diagnosed With Melioidosis In Pahang
2016 - 2019	Development of a Parallel biosensing system for personalized and pointof-care chemotherapy treatment
2010 - 2013	The Use of Multiplex Real-Time PCR for Differential Detection of Streptococcus Pneumoniae, Burkholderia pseudomallei and Atypical Bacterial Pathogens in Respiratory and Blood Samples of Patients with Community Acquired Pneumonia
2008 - 2010	Treatment Compliance among Lung Cancer Patient in Malaysia
2007 - 2014	Characterization of Burkholderia Pseudomallei and Evaluation and Modification of Available Serodiagnostic Tests for Melioidosis
2007 - 2014	Osteoporosis in Asthmatic Patients on Inhaled Corticosteroids
2006 - 2008	Monitoring Treatment Response of Patients With Smear Positive Pulmonary Tuberculosis
2004 - 2006	The Study of Musculoskeletal Meliodosis in Pahang
2004 - 2006	Study of Lung Function Among Traffic Police in Kuantan
2004 - 2017	Survey of Physicians and Patients on Awareness of Patients Rights, Attitudes, Practices and Role of Spirituallity and Holistic Medicine

On-Going

2022 - Present	Use of Interleukin-8 as a biomarker of predicting response to immunotherapy in advanced non-small cell lung cancer
2022 - Present	IIUM Health, Safety and Environment Unit (IHSEN)
2021 - Present	Polymerase Chain Reaction (PCR) Versus Blood Culture to Detect Burkholderia Pseudomallei Species in High Risk Patients with Suspected or Diagnosed with Melioidosis in Pahang
2011 - Present	One Best Answer - Internal Medicine
2010 - Present	Identification of Epidermal Growth Factor Receptor Mutation of Lung Cancer Patients in Malaysia
2010 - Present	Community-acquired Pneumonia in Hospital Tengku Ampuan Afzan, Kuantan
2008 - Present	The Use of An Air-Sealed Bag in Spontanoues Pneumothorax
-	24. A randomised, double-blind, double-dummy, placebo-controlled, parallel group study to assess the efficacy and safety of 48 weeks of once daily treatment of orally inhaled BI 1744 CL (5 ?g [2 actuations of 2.5 ?g] and 10 ?g [2 actuations of 5 ?g]) delivered by the Respimat? Inhaler, and 48 weeks of twice daily Foradil? (12 ?g) delivered by the Aerolizer? Inhaler, in patients with Chronic Obstructive Pulmonary Disease (COPD)
-	23. A comparison of Symbicort? Maintenance and Reliever Therapy (Symbicort Turbuhaler? 160/4.5ug, one inhalation bid plus as needed) and Symbicort Turbuhaler 160/4.5ug, one inhalation bid plus terbutaline Turbuhaler 0.4 mg/inhalation as needed, for treatment of asthma - a 12-month, randomized, double-blind, parallel group, active-controlled, multinational, phase III study in asthmatic patients aged 16 years and above.
-	18. International, multi-center, randomized, double blind study to compare the overall mortality in acutely ill medical patients treated with enoxaparin versus placebo in addition to Graduated Elastic Stokings
-	A phase 2/3 trial to assess the safety, immunogenicity and premalinary efficacy of recombinant human EGF-rP64K/ Montanide ISA 51 Vaccine administered to patients with NSCLC after receiving conventional first line chemotherapy.

06 Jul, 2012	Best Poster Presentation - Malaysian Thoracic Society	National
23 Jul, 2010	Best Poster Presentation - Malaysian Thoracic Society	National
23 Jul, 2010	2nd best oral presentation - Malaysian Thoracic Society	National
12 Apr, 2006	Promising Reseachers Award - IIUM	University
16 Jul, 2004	Best Oral presentation - Malaysian Thoracic Society	National

Article

2023	Five years melioidosis registry data from 2011 to 2015 in Pahang, Malaysia: a retrospective study. Bangladesh Journal of Infectious Diseases, 9 (1) pp. 7-14
2022	Application of real‑time cell analysis biosensor technology for drug cytotoxicity studies in primary lung cancer cells. Biomedical Materials & Devices, () pp. 1-12
2022	Hybrid de novo whole-genome assembly and annotation of SARS-CoV-2 Virus from nosocomial infection in Pahang, Malaysia. International Journal of Infectious Diseases, 116 () pp. S19-S19
2022	Near-complete whole-genome sequencing of two Burkholderia Pseudomallei strains harbouring novel molecular class d beta-lactamase genes, isolated from Malaysia. Microbiology Resource Announcement, () pp.
2022	Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia. Cancer Management and Research, 14 () pp. 1995-2005
2022	Real-world treatment and outcomes of ALK-positive metastatic non–small cell lung cancer in a southeast Asian country. Cancer Management and Research, () pp. 31-41
2022	Whole genome sequencing analysis of Spike D614G mutation reveals unique SARS-CoV-2 Lineages of B.1.524 and AU.2 in Malaysia. PLOS ONE, 17 (2) pp. 1-16
2021	Burkholderia pseudomallei short-chain dehydrogenase/ oxidoreductase: potential urine biomarker candidate for acute melioidosis. IIUM Medical Journal Malaysia, 20 (3) pp. 128-137
2021	Cancer-Associated Thrombosis: a clinical scoping review of the risk assessment models across solid tumours and haematological malignancies. International Journal of General Medicine, 14 () pp. 3881-3897
2021	Limited doses of immunotherapy use in advanced non-small cell lung cancer elderly patients with ECOG of 2 and high PDL-1 expression. Aging Medicine, () pp. 1-5
2021	Melioidosis in Pahang: a review from Registry Data 2011-2015. The Medical Journal of Malaysia, 76 () pp. 27
2021	Single dose of atezolizumab plus chemotherapy in active psoriasis with advanced non-small cell lung cancer. Journal of Oncology Pharmacy Practice, () pp. 1-4
2020	Asymptomatic coronavirus disease 2019 (COVID-19) carriers: are they infectious?. American Journal of Infectious Diseases and Microbiology, 8 (3) pp. 113-117
2020	Lung cancer in Malaysia. Journal of Theoretical Biology, 492 () pp. 317-323
2020	Seroconversion of indirect immunofluorescent antibody IgM and IgG in melioidosis. Bangladesh Journal of Infectious Diseases, 7 (2) pp. 61-66
2019	Depressive symptoms in newly diagnosed lung carcinoma: prevalence and associated risk factors. Tuberculosis And Respiratory Diseases, 82 (3) pp. 217-226
2019	Emerging respiratory infections threatening public health in the Asia-Pacific region: a position paper of the Asian Pacific Society of Respirology. Respirology, 24 (6) pp. 590-597
2019	Molecular testing for advanced non-small cell lung cancer in Malaysia: Consensus statement from the College of Pathologists, Academy of Medicine Malaysia, the Malaysian Thoracic Society, and the Malaysian Oncological Society. Lung Cancer, 136 () pp. 65-73
2019	Real-world experience of first-line afatinib in patients with EGFR-mutant advanced NSCLC: a multicenter observational study. BMC Cancer, 19 (1) pp. 1-11
2018	A case report of airway stenting in tracheal compression secondary to right subclavian artery pseudo-aneurysm. International Medical Journal Malaysia, 17 (1) pp. 141-144
2018	Melioidosis in Malaysia: Incidence, clinical challenges and advances in understanding pathogenesis. Tropical Medicine and Infectious Disease, 3 (1) pp. 1-19
2018	Melioidosis in Pahang. Asian Journal of Medicine and Biomedicine, 1 (Supplementary 1, 2018 (UICID 2018)) pp. 8-8
2017	Multiple cavitating pulmonary nodules secondary to Hodgkin's lymphoma. International Medical Journal Malaysia, 16 (2) pp. 129-131
2015	Asthma control in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia: a cross-sectional study. The International Medical Journal Malaysia, 14 (2) pp. 41-44
2015	First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study. Annals on Oncology Advanced, 19 (4) pp. 85-88
2015	Survival of lung cancer patients in a resource-limited country . Asia-Pacific Journal of Clinical Oncology, 11 (3) pp. 221-227
2015	The “crazy paving pattern” lung in a pregnant woman . Respirology, 20 (S3) pp. 81-81
2014	Epidermal growth factor receptor mutations in non- small cell lung cancers in a multiethnic Malaysian patient population. Asian Pacific Journal of Cancer Prevention, 15 (1) pp. 321-326
2014	Monitoring treatment response in sputum smear positive pulmonary tuberculosis patients: Comparison of weight gain, sputum conversion and chest radiograph. Malaysian Journal of Pathology, 36 (2) pp. 91-96
2012	A prospective study on epidermal growth factor receptor mutations in non-small cell lung cancer in Malaysian patients . Respirology, 17 (supp.2) pp. 90
2012	Airway Y-stent Insertion in Tracheobronchomalacia: A New Experience. The International Medical Journal Malaysia, 11 (1) pp. 51-53
2012	An asymptomatic young lady with multiple inflammatory myofibrolastic tumours. Journal of Clinical Case Reports, 2 (10) pp.
2012	Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country. Annals of Thoracic Medicine, 7 (2) pp. 69-73
2012	Case report: Fatal co-infection-melioidosis and leptospirosis. The American Journal of Tropical Medicine and Hygiene, 87 (4) pp. 737-740
2012	Defaulters among lung cancer patients in a suburban district in a developing country. Annals of thoracic medicine, 7 (1) pp. 12-15
2012	Fatal pneumonia following search and rescue operation. Respirology, 17 (supp.2) pp. 106
2012	Learning curve for double-balloon enteroscopy: findings from an analysis of 282 procedures. World Journal of Gastroenterology (WJG), 4 (8) pp. 368-372
2012	Outbreak of melioidosis and leptospirosis co-infection following a rescue operation. Medical Journal of Malaysia, 67 (3) pp. 293-297
2012	Outbreak of melioidosis and leptospirosis co-infection following a rescue operation.. The Medical journal of Malaysia, 67 (3) pp. 293-297
2012	Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia. Neurology Asia, 17 (2) pp. 93-99
2011	Development of multiplex real-time PCR for the rapid detection of five bacterial causes of community acquired pneumonia. Tropical Biomedicine, Vol 28 (3) pp. 545-556
2011	Empyema thoracis complicated by pneumothorax neccessitans manifesting as lobulated, localized subcutaneous emphysematous swellings. The Annals of Thracic Surgery, 91 () pp. 1969-1971
2011	Intrapleural streptokinase for the treatment of chylothorax. Respiratory Care, 56 (12) pp. 1953-5
2011	The bug and the big heart -- Melioidotic pericardial effusion. Medical Journal of Malaysia, 66 (1) pp. 71-72
2011	The use of multiplex real-time PCR improves the detection of the bacterial etiology of community acquired pneumonia. Tropical Biomedicine, 28 (3) pp. 531-544
2010	A survey on the initial management of spontaneous pneumothorax. Medical Journal of Malaysia, 65 (3) pp. 180-184
2010	Embolisation of a bronchial artery of anomalous origin in massive haemoptysis. Malaysian Journal of Medical Sciences , 17 (3) pp. 55-60
2010	Role of rigid bronchoscopy in massive haemoptysis. Journal of University of Malaya Medical Center, 13 (2) pp. 107-110
2010	Survival analysis among lung cancer patients in Pahang. Respirology, 15 (2) pp. 72-72
2010	The man with the boggy head: cranial melioidosis. Singapore Medical Journal, 51 (2) pp. e43-e45
2009	A mimicry of melioidosis by Klebsiella ozaenae infection. Malaysian Journal of Pathology, 31 (2) pp. 147-150
2009	Hospitalised patients' awareness of their rights: a cross-sectional survey from a tertiary care hospital on the east coast of Peninsular Malaysia. Singapore Medical Journal, 50 (5) pp. 494-499
2009	Lung cancer in Pahang Malaysia. Journal of Thoracic Oncology, 4 (9) pp. S657-S657
2009	Melioidotic prostatic abscess in Pahang. Singapore Medical Journal, 50 (4) pp. 385-389
2009	Pahang melioidosis registry. Medical Journal of Malaysia, 64 (1) pp. 27-30
2009	Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan. Medical Journal of Malaysia, 64 (4) pp. 263-267
2008	An unusual cause of haemoptysis and headache: cryptococcosis. The Malaysian Journal of Pathology, 30 (2) pp. 129-32
2008	Intrapulmonary bronchogenic cyst: Single case report. Journal of University of Malaya Medical Center, 11 (2) pp. 86-88
2008	Medical thoracoscopy: Pahang experience. Medical Journal of Malaysia, 63 (4) pp. 298-301
2008	Melioidosis prostatic abscess: clinical presentation and imaging findings. International Medical Journal Malaysia, 7 (1) pp. 1-8
2008	The urine bag used in pneumothorax. The Medical Journal of Malaysia, 63 (1) pp. 79-80
2008	Transbronchial needle aspiration of mediastinal lymph node. Medical Journal of Malaysia, 63 (1) pp. 47-50
2007	Awareness, knowledge and attitude towards informed consent among doctors in two different cultures in Asia: a cross-sectional comparative study in Malaysia and Kashmir, India. Singapore Medical Journal, 48 (6) pp. 559-565
2007	Perception of the Islamic ruling on smoking among muslim adults in Malaysia; a preliminary survey. International Medical Journal Malaysia, 6 (2) pp. 1-9
2007	Perception of the Islamic ruling on smoking among Muslims. Respirology, () pp. A223
2006	A case of lymphangioleiomyomatosis with multiple angiomyolipomas in the kidneys: a case report. Journal of Health and Translational Medicine, 6 (2) pp. 35-38
2006	Do patients’ understanding of diabetes and perception of control predict higher Hba1c and complications?. International Medical Journal Malaysia, 5 (1) pp. 1-18
2006	Edwardsiella tarda septicemia with underlying multiple liver abscesses. The Malaysian Journal of Pathology, 28 (1) pp. 49-53
2006	Infective endocarditis in the East coast of peninsular Malaysia: a two year retrospective survey from Kuantan. JK-Practitioner, 13 (1) pp. 5-8
2006	Managing congestive heart failure in a general hospital in Malaysia. Are we keeping pace with evidence?. The Medical Journal of Malaysia, 61 (3) pp. 278-83
2006	Melioidosis: a potentially life threatening infection. The Medical Journal of Malaysia, 61 (3) pp. 386-395
2006	Pleural effusions: role of commonly available investigations. Singapore Medical Journal, 47 (7) pp. 609-613
2006	Serum cancer antigen 125 in patients with pleural effusions. The Medical Journal of Malaysia, 61 (5) pp. 558-563
2005	Melioidosis in Pahang, Malaysia. The Medical Journal of Malaysia, 60 (5) pp. 606-613
2005	Pediatric melioidosis in Pahang, Malaysia. Journal of Microbiology, Immunology and Infection, 38 (5) pp. 314-319
2005	Pulmonary melioidosis: a review of 70 cases from Pahang, Malaysia . International Medical Journal Malaysia, 4 (1) pp. (1-7)
2004	Empyesematous pyelonephritis. International Medical Journal Malaysia, 3 (1) pp. 1
2003	Metabolic changes during ramadan fasting in normal people and diabetic patients. International Medical Journal Malaysia, 2 (2) pp.
2003	Quadriparesis with lower motor neuron signs and absent sensory involvement. International Medical Journal Malaysia, 2 (1) pp.

Conference or Workshop Item

2021	Hybrid de novo Whole-Genome Assembly and Annotation of SARS-CoV-2 Virus from Nosocomial Infection in Pahang, Malaysia. In: International Meeting on Emerging Diseases and Surveillance 2021,
2021	Melioidosis in Pahang: a review from registry data 2011-2015. In: 14th National Conference for Clinical Research (NCCR) 2021,
2019	Advanced interior mediastinal yolk sac tumor with superior vena cava syndrome (SVCS). In: Malaysian Thoracic Society Congress 2019,
2019	Endobronchial Pseudo-tumor caused by herpes simplex. In: Malaysian Thoracic Society Congress 2019,
2019	Lactobacillus catenaformis associated lung empyema. In: Malaysian Thoracic Society Congress 2019,
2019	Malignant lung carcinoid tumour. In: Malaysian Thoracic Society Congress 2019,
2019	Pleuropulmonary solitary fibrous tumour (SFT). In: Malaysian Thoracic Society Congress 2019,
2019	Real-world multicentre experience of first-line afatinib in patients with EGFR-mutant advanced non-small cell lung cancer. In: IASLC World Conference on Lung Cancer 2019,
2019	The use of active melioidosis detect tm in early diagnosis of melioidosis in Hospital Tengku Ampuan Afzan and Hospital Sultanah Nurzahirah. In: Medical Research Symposium 2019: Expanding Research Collaboration in Health,
2018	Doege Potter syndrome. In: Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress 2018,
2018	Lung carcinoid tumour. In: Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress 2018,
2015	Unexpected case of ankle tuberculosis in a young professionals leading to delay in diagnosis. In: 36th SICOT Orthopaedic World Congress,
2013	Dealing with lung cancer complications: how aggressive can we be?. In: Malaysian Thoracic Society Annual Congress 2013,
2013	Diffuse panbronchiolitis mimicking miliary pulmonary tuberculosis. In: Malaysian Thoracic Society Annual Congress 2013,
2013	Fatal pneumonia following search and rescue operation. In: 7th World Melioidosis Congress,
2013	Prevalence and risk factors of drug resistant pulmonary tuberculosis in Hospital Tengku Ampuan Afzan and Hospital Selayang. In: Malaysian Thoracic Society Annual Congress 2013,
2013	Pulmonary tuberculosis: co-morbidities, drug susceptibility and its association with clinical outcomes. In: Malaysian Thoracic Society Annual Congress 2013,
2012	Asthma control in HTAA, Kuantan: a cross sectional study. In: Malaysian Thoracic Society Annual Congress 2012,
2011	Predictors of in-hospital mortality in primary intracerebral haemorrhage in rural Malaysia. In: Asia Pacific Stroke Conference 2011,
2010	Community-acquired pneumonia in Hospital Tengku Ampuan Afzan. In: Pahang Research Day 2010 ,
2010	Sputum conversion, weight and chest radiograph changes among smear positive pulmonary tuberculosis patients . In: Pahang Research Day 2010 ,
2009	Predictors of in-hospital mortality in primary intracerebral hemorrhage in rural Malaysia. In: 19th World Congress of Neurology,
2008	A chicken bone that made her groan-swallowed chicken bone complicated empyema thoracis. In: 13th Congress of the Asian Pacific Society of Respiralogy,
2008	Acute Endobronchial obstruction from massive Haemoptysis . In: 10th Annual Congress of the Malaysian Thoracic Society,
2008	Bone mineral density in patients with bronchial asthma on inhaled corticosteroids. In: 10th Annual Congress of the Malaysian Thoracic Society,
2008	Case report: a bleeding abscess-massive massive Haemoptysis from a Lung abcess. In: 13th Congress of the Asian Pacific Society of Respiralogy,
2008	Case report. A chicken bone that made her groan-swallowed chicken bone compicated by Empyema Thoracis . In: 10th Annual Congress of the Malaysian Thoracic Society,
2008	Transbronchial needle aspiration of mediastinal lymph node. In: 13th Congress of the Asian Pacific Society of Respiralogy,
2008	Transbronchial needle aspiration of mediastinal lymph node . In: 10th Annual Congress of the Malaysian Thoracic Society,
2008	Transthoracic biopsy: Local experience in Kuantan, Pahang . In: 10th Annual Congress of the Malaysian Thoracic Society,
2008	Treatment compliance among lung cancer patient in Malaysia. In: 13th Congress of the Asian Pacific Society of Respiralogy,
2008	Treatment compliance among lung cancer patient in Malaysia. In: 10th Annual Congress of the Malaysian Thoracic Society,
2007	Burkholderia pseudomallei infection in children . In: 5th World Melioidosis Congress,
2007	Musculoskeletal melioodosis. In: Fifth SICOT/SIROT Annual International Conference 2007,
2007	Pahang meliodosis registry . In: 5th World Melioidosis Congress,
2007	Pulmonary melioidosis: a review of 70 cases from Pahang, Malaysia. In: 5th World Melioidosis Congress,
2007	Pulmonary Melioidosis: A review of 70 cases from Pahang, Malaysia. In: The 12nd Congress of Asian Pacific Society of Respirology,
2007	Pulmonary melioidosis: Clinical radiological correlation in Pahang, Malaysia. In: 5th World Melioidosis Congress,
2007	Rare presentation of burholderia psedomallei infection. In: 12th ASEAN ORL Head and Neck Congress,
2005	Endobronchial actinomycosis: Is a repeat bronchoscopy after treatment necessary? . In: 8th Annual Congress of the Malaysian Thoracic Society ,
2005	Pulmonary Melioidosis: A review of 70 cases from Pahang. In: 8th Annual Congress of the Malaysian Thoracic Society ,
2005	Serum and pleural fluid cancer antigen 125 (ca125) levels in patients with pleural effusions. In: 8th Annual Congress of the Malaysian Thoracic Society ,
2004	The role of pleural fluid analysis, pleural biopsy and bronchoscopy in neoplastic and tuberculous pleural effusion . In: 7th Annual Congress of the Malaysian Thoracic Society,
2002	The utility of tumours markers in the diagnosis of neoplastic pleural effusions . In: 5th Annual Congress of the Malaysian Thoracic Society,