Staff Directory


Khairani Idah Binti Mokhtar @ Makhtar

Academic Qualification

  • Doctor of Philosophy in Developmental Biology - Doctor of Philosophy, University of Manchester
  • Master of Science (Medical Science) - Masters Degree, Universiti Sains Malaysia (USM)
  • Bachelor of Science (Infection & Immunity, Pharmacology) - Bachelor Degree, University of Adelaide

Khairani Idah Binti Mokhtar @ Makhtar (Assoc. Prof. Datin Dr.)

Associate Professor
IIUM Kuantan Campus

KULLIYYAH OF DENTISTRY

drkhairani@iium.edu.my
5519


Expert Profile


Associate Professor Datin Dr. Khairani Idah Mokhtar@Makhtar is currently a lecturer from Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, IIUM Kuantan Campus. Dr Khairani started her early career in academia as a lecturer and a researcher at School of Dental Sciences, USM from 2008-2014 before joining Kulliyyah of Dentistry, IIUM in August 2014. In IIUM, she was previously the Deputy Dean of Postgraduate and Research of the Kulliyyah of Dentistry (2017-2021). Prior, she was appointed as the Deputy Director of Research Management Center (RMC) for Kuantan Campus (2015-2016). She obtained her first degree in Bachelor of Science (Infection & Immunity, Pharmacology), from University of Adelaide, Australia. Later continued her master's degree in MSc in Medical Sciences from USM and finally obtained her Doctor of Philosophy in Developmental Biology from University of Manchester in 2008.  Her specialized field is in craniofacial genetics, looking into developmental process of craniofacial development particularly secondary palate development.  She is also involved in dental stem cells study and is also interested in natural products for tissue regeneration process. Besides looking into the genetic aspects of craniofacial development (Cleft, malocclusion); her research areas also involve studies looking on the effects of natural products extracts on osteogenic differentiation potential of dental stem cells, with the ultimate aim to be applied in tissue regeneration process. Her interest in fundamental research has enabled her to secure multiple research grants in collaborations with other researchers from other institutions. She has; to her credit, successfully published papers related to her areas of specialization. Subsequently, with regards to her area of specialization, Dr Khairani is also a Life Member of Malaysian Society of Human Genetics (MSHG), Tissue Engineering and Regenerative Medicine Society of Malaysia (TESMA) as well as Malaysian Biomaterials Society (MBS). In Kulliyyah of Dentistry, she is currently teaching part of Biochemistry and Oral Biology courses. She is also the course coordinator for Year 5 Research subject for BDS undergraduate programme.


Area of Specialisation


  • Medical And Health ~ Medical And Health Sciences ~ Dentistry ~ Oral Biology - Craniofacial development-palate
  • Medical And Health ~ Medical And Health Sciences ~ Biomedical Sciences ~ Stem Cells - Dental Stem Cells
  • Natural Science ~ Biological Sciences ~ Genetics ~ Molecular Genetics - Craniofacial genetics


Professional Membership


  • 2008: Member of Profesional Body / Association, University of Adelaide Alumni
  • 2010: Member of Profesional Body / Association, University of Manchester Alumni
  • 2015 - 2022: Member of Profesional Body / Association: (Ordinary Member), International Association for Dental Research-Malaysian Section (South East Asian Division)
  • 2015: Member of Profesional Body / Association: (Life Member), Malaysian Society of Human Genetics (MSHG)
  • 2015: Member of Profesional Body / Association: (Life Member), Malaysian Biomaterials Society (MBS)
  • 2016 - 2017: Member of Profesional Body / Association: (Ordinary Member), Tissue Engineering & Regenerative Medicine Society of Malaysia
  • 2016 - 2017: Member of Profesional Body / Association: (Ordinary Member), International Association for Dental Research-Malaysian Section (South East Asian Division)
  • 2018: Member of Profesional Body / Association: (Life Member), Persatuan Perkembangan Kesihatan Wanita Kota Bharu, Kelantan
  • 2020: Member of Profesional Body / Association: (Life Membership), Tissue Engineering & Regenerative Medicine Society of Malaysia (TESMA)


Teaching Responsibilities


BIOCHEMISTRY 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019 2017/2018 2015/2016
ORAL BIOLOGY 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019 2017/2018 2015/2016 2014/2015
RESEARCH (LITERATURE REVIEW) 2017/2018
Research Project 2019/2020 2018/2019 2017/2018 2015/2016
RESEARCH PROPOSAL 2017/2018
RESEARCH YEAR 4 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019
RESEARCH YEAR 5 2022/2023 2021/2022 2020/2021 2019/2020


Research Projects


Completed
2019 - 2021 Development, Characterization and Invitro Study of Flax Seed Oil Ointment for Wound Healing
2019 - 2023 Specific orthodontic tooth movement (OTM) biomarkers-related gene expression and hormonal changes induced by mechanical transduction on various mechanisms of orthodontic traction
2019 - 2022 Empowering the Knowledge of Caretaker for Improvement of Oral Health Status of Children with Disabilities at Special Needs School in Kuantan
2018 - 2021 TRANSFERRING KNOWLEDGE OF ORAL HEALTH TO CARERS IN SELECTED ELDERLY CARE HOME IN KUANTAN TOWARDS IMPROVING ORAL HEALTH STATUS OF THE RESIDENTS.
2017 - 2021 Epithelization, ossification and gene expression of the socket after tooth extraction in diabetic rats treated by flax seed extract
2016 - 2019 Immunological, Histopathological and Gene Expression Changes Induced by Flax Seed Extract during Wound Healing Process
2015 - 2018 Clinical, Radiographic and genetic Evaluation of Non-Syndromic Hypodontia in Malaysia Population
2015 - 2020 Flax seed extract and its effect on WNT signaling pathway in the osteogenic differentiation potential of stem cells from human exfoliated deciduous teeth (SHED)
2015 - 2018 Detection of Myo1H, Pax9 and Runx2 Single Nucleotide polymorphism and its Association in Different Classes of Dental Malocclusion.
On-Going
2022 - Present Characterization on the Properties of Mitragyna Speciosa, Deletion of Toxicity Genes, Development of Kratom-Based Medicinal Products and It's Legal Implication
2022 - Present Elucidating the prophylactic potential of Kelulut honey in modulating angiotensin-converting enzyme 2 (ACE2) as COVID-19 target enzyme
2021 - Present Salivary Leptin as a Potential Early Diagnostics Tumour Markers in Suspected Oral Cancer Patients Attending SASMEC
2021 - Present Genetic Analysis of LEP-2548G/A and LEPR Gene Gln223Arg Polymorphism (rs1137101) in Patients with Oral Cancer: A Preliminary Study at SASMEC @IIUM
2021 - Present The Effect of Flaxseed Extract as Bioactive Titanium Coating Material In-Vitro
2021 - Present Goniothalamus umbrosus. A potential chemo-preventive and anti-carcinogenic agent for oral squamous cell carcinoma
2021 - Present Modulation of osteogenic differentiation of stem cells from human exfoliated deciduous teeth (SHED) treated with Malayan deer antler velvet extract seeded on chitosan scaffold
2020 - Present Effect of flaxseed (Linum usitatissimum) extract on oral wound healing demonstrated through fibroblast and osteoblast co-culture: an in-vitro analysis
2019 - Present HIGH-RISK GENOTYPE HPV AND HSV-1 DETECTION ISOLATED FROM BUCCAL SWAB AND UNSTIMULATED SALIVA AND ITS ASSOCIATION WITH ORAL LESIONS AMONG TRANSGENDER PRACTISING HIGH RISK BEHAVIOUR IN MALAYSIA
2019 - Present STUDY ON THE PHYSICAL AND CHEMICAL CHARACTERISTICS OF SALIVA OBTAINED FROM SPECIAL NEEDS CHILDREN WITH CARIES
2019 - Present Analysing the prevalence of tooth wear and its associated factors among secondary school children for the improvement of the oral health status.
2015 - Present Antimicrobial action of Flaxseed and Nigella sativa oil on selected oral pathogen in intracanal environment


Award & Recognition


26 Oct, 2022 GOLD-CERTIFICATE OF AWARD- RISE 2022 - UTHM International
15 Sep, 2022 GOLD MEDAL AWARD- IRID 2022-CERTIFICATE OF EXCELLENCE - Others University
15 Sep, 2022 SILVER MEDAL AWARD- IRID 2022- Certificate of Excellence - Others University
28 Mar, 2022 GOLD MEDAL AWARD- 11th DSSC 2022- CERTIFICATE OF EXCELLENCE - KULLIYYAH OF DENTISTRY, IIUM KCDIO
28 Mar, 2022 SILVER MEDAL AWARD- 11th DSSC 2022- CERTIFICATE OF EXCELLENCE - KULLIYYAH OF DENTISTRY KCDIO
10 Dec, 2021 CONGRATULATORY- HIGHEST TOP RESEARCHERS OF JOINT PUBLICATION FOR 2019-2021 (KULLIYYAH OF DENTISTRY) - Others University
24 Nov, 2021 GOLD MEDAL AWARD- IIUM RESEARCH DAY 2021 - Others University
24 Nov, 2021 BEST STAFF AWARD (BASIC SCIENCES) in IIUM RESEARCH DAY 2021 - Others University
29 Oct, 2021 MERIT AWARD- Sustainable Development Goals International Innovation Awards - Malaysia Technology Expo (MTE 2021) International


Publications


Article

2023 Effect of flaxseed on TGF-Β, IL-6, and MMP9 genes expression during wound healing process in rabbits. Open Access Macedonian Journal of Medical Sciences, () pp. 41-46
2023 Exploring past experience of becoming a transgender woman: perspective from Malaysian Muslim transgender women: a qualitative study. Journal of International Dental and Medical Research, 16 (1) pp. 224-230
2022 Application of dental stem cell in dentistry: where are we now?. IIUM Journal of Orofacial and Health Sciences, 3 (1) pp. 81-83
2021 Effect of horseshoe crab perivitelline fluid on the viability of stem cells from human exfoliated deciduous teeth and expression of cell cycle regulatory genes. Indian Journal of Geo-Marine Sciences (IJMS), 50 (2) pp. 87-96
2021 Effects of flaxseed (linum usitatissimum) extract on osteoblast differentiation potential of stem cells derived from human exfoliated deciduous teeth. Makara Journal of Health Research, 25 (1) pp. 1-7
2020 Amniotic membrane enhance the effect of vascular endothelial growth factor on the angiogenic marker expression of stem cells from human exfoliated deciduous teeth. Applied Biochemistry and Biotechnology, 191 () pp. 177-190
2020 Application of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in the analysis of MYO1H single nucleotide polymorphism in Malay mandibular prognathism patients. Archives of Orofacial Sciences, 15 (2) pp. 139-147
2020 Demographics and clinical profile of orofacial cleft in International Islamic University Malaysia from 2009 until 2018. Archives of Orofacial Sciences, 15 (2) pp. 97-107
2020 Distribution of FC gamma receptor IIa genotypes among Malay patients with periodontitis. International Journal of Dentistry and Oral Science, 7 (11) pp. 907-911
2020 Flaxseed (Linum usitatissimum) extract activity on human oral fibroblasts (HOrF) cell line. Annals of Dentistry University of Malaya, 27 (8) pp. 50-54
2020 Genetics of malocclusion: a review. International Journal of Orofacial and Health Sciences, 1 (1) pp. 4-10
2020 Histopathological changes of the flaxseed extract on skin wound healing in diabetic rabbits. Open Access Macedonian Journal of Medical Sciences, 8 (A) pp. 881-892
2020 Potential antibacterial effects of flaxseed and Nigella sativa extracts on 11 streptococcus pyogenes. International Journal of Orofacial and Health Sciences, 1 (1) pp. 11-17
2020 Potential effects of flaxseed (Linum usitatissimum) in tissue reparative processes: a mini review. Journal of Biomedical and Clinical Sciences (JBCS), 5 (1) pp. 1-7
2019 Class III malocclusion: missense mutations in DUSP6 gene. Pesquisa Brasileira em Odontopediatria e Clínica Integrada / Brazilian Research in Pediatric Dentistry and Integrated Clinic (PBOCI), 19 (1) pp. 1-8
2019 Human amniotic membrane as a matrix for endothelial differentiation of VEGF-treated dental stem cells. Cellular and Molecular Bioengineering, Vol. 12 (6) pp. 599-613
2019 Potential applications of horseshoe crab in biomedical research. Journal of Biomedical & Clinical Science, 4 (2) pp. 12-18
2019 The antimicrobial effect of flax seed on pseudomonas aeruginosa. World Journal of Pharmacy and Pharmaceutical Sciences, 8 (9) pp. 629-642
2019 The effect of flaxseed extract on skin elasticity of the healing wound in rabbits. The International Medical Journal Malaysia, 18 (1) pp. 5-12
2019 The potential effect of different types of flaxseed (Linum usitatissimum) extract on the cell viability of oral fibroblasts human cell line. International Journal of Allied Health Sciences, (3: Special Issue: Research Towards Sustainable Development Goals) pp. 829-829
2018 A preliminary study on MYO1H single nucleotide polymorphism (rs10850110) in mandibular prognathism in Malay population. Journal of International Dental and Medical Research, 11 (2) pp. 607-613
2018 Calcium chloride dihydrate affects the biological properties of white mineral trioxide aggregate on dental pulp stem cells: An in vitro study. Saudi Endodontic Journal, 8 (1 (January-April)) pp. 25-33
2018 Evaluation of bioactive compounds in different extracts of Linum usitatissimum and their antibacterial properties. Makara Journal Health Research, 22 (3) pp. 121-127
2018 Flaxseed ethanolic crude extract influences growth of stem cells from human exfoliated deciduous teeth (SHED). Journal of International Dental and Medical Research, 11 (2) pp. 643-649
2018 Linum usitatissimum as an antimicrobial agent and a potential natural healer: a review. Archives of Orofacial Sciences, 13 (2) pp. 55-62
2018 Preliminary study of PAX9 single nucleotide polymorphism (rs8004560) in patients with Class II skeletal base malocclusion contributed by mandibular retrognatism. Archives of Orofacial Sciences, 13 (2) pp. 112-118
2018 The anti-fungal effect of flax seed on oral candidiasis: comparative in-vitro study. Journal of International Dental and Medical Research, 11 (2) pp. 580-586
2018 The antibacterial effect of flaxseed extract on selective oral pathogens - comparative in vitro study. World Journal of Pharmacy and Pharmaceutical Sciences, 7 (11) pp. 1-11
2018 The effect of flaxseed extract on skin elasticity of the healing wound in rabbit. Asian Journal of Medicine and Biomedicine, Supplementary 3 () pp. 109
2017 Analysis Of MYO1H single nucleotide polymorphism in class III malocclusion with mandibular prognathism: A preliminary study. The International Medical Journal of Malaysia, 16 (Supplementary Issue No 2) pp. 1-1
2017 Demographic characteristics and analysis of malocclusions of orthodontic patients seen at IIUM Dental Specialist Clinic, Kuantan, Pahang. International Medical Journal Malaysia, 16 (2) pp. 107-111
2017 Dentinogenic differentiation potential of fast set white portland cements of a different origin on dental pulp stem cells. European Journal of General Dentistry, 6 (3) pp. 115-122
2017 Identification and Characterization of Intraoral and Dermal Fibroblasts Revisited. Current Stem Cell Research & Therapy, 12 (8) pp. 1-7
2017 White mineral trioxide aggregate mixed with calcium chloride dihydrate: chemical analysis and biological properties. Restorative Dentistry & Endodontics, 42 (3) pp. 176-187
2016 10 years review of endowment fund for research in IIUM Kuantan. international Medical Journal of Malaysia, 15 (Supplement Issue) pp. 25-25
2016 Angiogenic potential of extracellular matrix of human amniotic membrane. Tissue Engineering and Regenerative Medicine, 13 ( 3) pp. 211-217
2016 Anticancer properties of Malaysian herbs: a review. Archives of Orofacial Sciences, 11 (2) pp. 19-25
2016 Chemical analysis and biological properties of two different formulations of white portland cements. Scanning, 38 (4) pp. 303-316
2016 Craniofacial morphology of class III malocclusion with DUSP6 gene: Mutation and non-mutation groups. Journal of Hard Tissue Biology, 25 (3) pp. 247-256
2016 Effect of perivitelline fluid from horseshoe crab on the expression of cell cycle regulatory genes in human dental pulp stem cells. Archives of Orofacial Sciences, 11 (1) pp. 7-14
2016 Effects of flaxseed extract on the viability of stem cells from human extracted deciduous teeth (SHED). Frontiers in Bioengineering and Biotechnology, () pp. 1-2
2016 Latent class analysis of dental treatment: Observed in IIUM dental specialist clinic, Kuantan, Pahang. International Medical Journal Malaysia, 17 (Special issue: 2) pp. 313-318
2015 Cementoblastic lineage formation in the cross-talk between stem cells of human exfoliated deciduous teeth and epithelial rests of Malassez cells. Clinical Oral Investigation, () pp.
2015 Effects of perivitelline fluid obtained from horseshoe crab on the proliferation and genotoxicity of dental pulp stem cells. Cell Journal, 17 (2) pp. 253-263
2015 Expression analysis of notch signaling pathway molecules in SHED cultured in keratinocyte growth medium. Brazilian Journal of Oral Sciences, 14 (2) pp. 135-140
2015 Morphological change of shed and the effect of VEGF on amniotic membrane scaffold. Malaysian Journal of Microscopy, 11 () pp. 1-6
Conference or Workshop Item

2022 70% Ethanolic flaxseed extract enhances SaOS-2 cell proliferation in bone wound-healing model (In-Vitro). In: IIUM Research and Innovation Day 2022 (IRID 2022),
2022 Flaxseed (linum usitatissimum) ethanolic extract affects WNT signalling pathway-associated molecules; β-catenin and DKK1 expressions, during osteoblast differentiation of SHED. In: The 13th INTERNATIONAL SYMPOSIUM OF HEALTH SCIENCES,
2021 Wound healing activity of flaxseed (Linum usitatissimum) extract (water and ethanol) on human oral fibroblast cells (in vitro). In: 4th International Conference on Oral Microbiology and Oral Immunology,
2019 Effects of flaxseed (Linum usitatissimum) extract on osteoblast differentiation potential of stem cells derived from human exfoliated deciduous teeth (SHED). In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019),
2019 Effects of flaxseed extract on skin wound healing in animal model. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019),
2019 The potential effect of different types of flaxseed (linum usitatissimum) extract on the cell viability of oral fibroblasts human cell line. In: Kuantan Research Day 2019 (KRD 2019),
2019 The effect of flaxseed extract on genes expression during wound healing process in rabbit. In: International Conference on Pharmaceutical Research and Pharmacy Practice cum 14th IIUM-MPS Pharmacy Scientific Conference (ICPRP 2019),
2018 Linum usitatissimum antibacterial activity on Pseudomona Aerigenosa in-vitro study. In: The International Conference on Oral Immunology & Oral Microbiology (ICOIOM) 2018,
2018 RUNX2 single nucleotide polymorphism (rs6930053) in Class II malocclusions patients: a preliminary study. In: 3rd ASEAN Congress on Medical Biotechnology and Molecular Biosciences,
2018 Stem cells-endothelial differentiation in 3D in vitro model. In: 2nd International Conference on Medical and Health Sciences and 23rd National Conference on Medical and Health Sciences,
2018 The effect of flaxseed extraction on skin elasticity of the healing wound in rabbit. In: 3rd ASEAN Congress on Medical Biotechnology and Molecular Biosciences,
2017 Analysis Of MYO1H single nucleotide polymorphism in class III malocclusion with mandibular prognathism: A preliminary study. In: 1st IIUM International Dental Conference 2017 in Commemoration of the Kulliyyah of Dentistry 10th Anniversary (1st IIDC),
2017 Determination of RUNX2 single nucleotide polymorphism rs6930053 in class I, II and III malocclusions. In: 1st IUM International Dental Conference 2017 (IIDC),
2017 Genetic mutation and its effect on craniofacial morphology in Malaysian family with class III malocclusion. In: 16th Annual Scientific Meeting & 18th Annual General Meeting of Malaysian Section IADR,
2017 Identification and detection of bioactive compounds in Linum usitatissimum (Flaxseed) and its antibacterial properties against selected oral pathogens. In: 6th International Conference on Advancement in Science and Technology (iCAST 2017),
2017 Identification of PAX9 single nucleotide polymorphism in class III malocclusion patients with mandibular prognatism. In: 1st IIUM International Dental Conference 2017 in Commemoration of the Kulliyyah of Dentistry 10th Anniversary (1st IIDC),
2017 Study on flaxseed crude extract on stem cells from human exfoliated deciduous teeth (SHED). In: 1st IIUM International Dental Conference 2017 in Commemoration of the Kulliyyah of Dentistry 10th Anniversary (1st IIDC),
2016 Craniofacial morphology of Class lll malocclusion in relation with genetic mutation. In: 21st National Conference on Medical and Health Sciences 2016,
2016 Effect of NF-kB inhibitors on its protein expression of stem cells from human extracted deciduous teeth cultured on amniotic membrane scaffold. In: National Colloquium on Stem Cell Research 2016,
2016 Effect of Transforming Growth Factor-Beta signalling on SHED cultured in keratinocytes differentiation medium treated with TGF-B1 and ALK-5 inhibitor. In: National Colloquium on Stem Cell Research 2016,
2016 Effect of vascular endothelial growth factor on stem cell and angiogenic gene markers of stem cell from human extracted deciduous teeth. In: National Colloquium on Stem Cell Research 2016,
2016 Effects of flaxseed extract on the viability of stem cells from human exfoliated deciduous teeth. In: 6th MTERMS (Malaysian Tissue Engineering and Regenerative Medicine Scientific Meeting) 2016 in conjunction with 2nd Malaysian Stem Cell Meeting,
2016 Effects of Interleukin-8 and its inhibition on phosphatidylinositide 3-kinase (P13K) pathway in stem cells from human exfoliated deciduous teeth: a prelimenary study. In: National Colloquium on Stem Cell Research 2016,
2016 Expression of protein stem cell markers by stem cells from human extracted deciduous teeth at different passages. In: National Colloquium on Stem Cell Research 2016,
2016 Optimisation of western blot technique for detection of interleukin-8 (IL-8) in stem cells from human exfoliated deciduous teeth (SHED). In: National Colloquium on Stem Cell Research 2016,
2015 Proliferative and genotoxic effect of Perivitelline fluid from horseshoe crab on human dental pulp stem cells. In: ISSCR 2015 Annual Meeting,
2015 TGFβ-1 and ALK5 inhibitor treatment affects expressions of TGF β signalling pathway associated molecules in SHED cultured in keratinocyte growth medium. In: 22nd Annual Scientific Meeting of Malaysian Society for Molecular Biology and Biotechnology,
Book

2022 Compendium of dental sciences research. Kulliyyah of Dentistry, International Islamic University Malaysia, ISBN:
2022 MANUAL FOR IBADAH CAMP ORGANIZER A PART OF THE IIUM FLAGSHIP ENTITLED “GENDER DYSPHORIA”. IIUM Press, ISBN: 978-629-97442
2022 MANUAL FOR IBADAH CAMP ORGANIZER A PART OF THE IIUM FLAGSHIP ENTITLED “GENDER DYSPHORIA”. IIUM Press, ISBN: 978-629-97442
2017 Cleft lip and palate: An overview. Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia, ISBN: 978-967-12682-9-2
2016 Dental stem cells culturing for the future. Penerbit Universiti Sains Malaysia, ISBN: 978-983-861-912-7
Book Section

2022 A pilot study on expectation and satisfaction of denture patients in IIUM dental clinic. In: Kulliyyah of Dentistry IIUM, ISBN: , pp. 47-72
2022 A pilot study on expectation and satisfaction of denture patients in IIUM dental clinic. In: Kulliyyah of Dentistry IIUM, ISBN: , pp. 47-72
Monograph

2020 Flaxseed extract and its effect on wnt signaling pathway in the osteogenic differentiation potential of stem cells from human exfoliated deciduous teeth (shed).. In: ,