Staff Directory

Fazia Adyani binti Ahmad Fuad

Academic Qualification

  • PhD (Structural Biochemistry) - Doctor of Philosophy, University of Edinburgh
  • MSc (Plant Biotechnology) - Masters Degree, Universiti Kebangsaan Malaysia (UKM)
  • BSc (Biochemistry) - Bachelor Degree, Universiti Kebangsaan Malaysia (UKM)

Fazia Adyani binti Ahmad Fuad (Assoc. Prof. Dr.)

Associate Professor
IIUM Gombak Campus


Expert Profile

Fazia Adyani Ahmad Fuad is an Assistant Professor at the Department of Biotechnology Engineering, Faculty of Engineering. Fazia's academic path began with a BSc (Biochemistry), which was obtained from University Kebangsaan Malaysia (UKM) in 2004. She then furthered her studies for a Master's degree at the same institution, specialising in Plant Biotechnology and successfully completed her studies in 2008.
She later pursued her doctoral degree (Structural Biochemistry) at the University of Edinburgh, Scotland, UK. She was awarded her Ph.D in 2012 and served as a lecturer at Institute for Research in Molecular Medicine (INFORMM), Health Campus, University Science Malaysia, before joining IIUM in 2014. Fazia's Ph.D project focused on drug design and discovery analyses on specific protein targets, in collaboration with Université Catholique de Louvain, Brussels and National Institutes of Health (NIH), USA. Since then, she has published her work in a number of international conferences and ISI-indexed journals.
She also serves as an editorial review board for International Journal in Medical Sciences and Biotechnology, and a member of several international scientific societies. Currently, Fazia is interested in investigating the potential of specific enzymes that are involved in various metabolic pathways as chemotherapeutic targets. Her main interests include a combination of in silico drug design and biochemical analyses on specific protein targets, which allows further understanding of various protein-protein and protein-ligand interactions.

Area of Specialisation

  • Natural Science ~ Bioinformatics ~ Systems Biology ~ Other Systems Biology n.e.c. - Biology
  • Natural Science ~ Bioinformatics ~ Structural Bioinformatics ~ Structural Proteomics - Proteomics
  • Biotechnology ~ Biotechnology ~ Biopharmacy Biotechnology ~ Drug Discovery - Drug Design & Discovery
  • Natural Science ~ Biological Sciences ~ Biochemistry ~ Proteins - Structural Biochemistry & Molecular Biology

Professional Membership

  • 2011: Member of Profesional Body / Association: (Member), Biochemical Society, UK
  • 2015: Member of Profesional Body / Association: (Member), Royal Society of Chemistry (RSC), UK
  • 2018: Member of Profesional Body / Association: (Member), Bioinformatics and Computational Biology Society Malaysia (MASBIC)
  • 2019: Member of Profesional Body / Association: (Senior Member), Hong Kong Chemical, Biological & Environmental Engineering Society (HKCBEES), Hong Kong
  • 2020: Member of Profesional Body / Association: (Member), Abu Hurairah Animal Society
  • 2021: Member of Profesional Body / Association: (Member), Abu Hurairah Animal Society IIUM
  • 2022: Member of Profesional Body / Association: (Applied fo Membership), Malaysia Society for Engineering & Technology (MySET)
  • 2022: Member of Profesional Body / Association: (Graduate Technologist), Malaysia Board Of Technologists (MBOT)

Teaching Responsibilities

BIOCHEMISTRY 2022/2023 2021/2022
BIOTECHNOLOGY ENGINEERING LAB III 2023/2024 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019 2017/2018 2016/2017 2015/2016
MOLECULAR BIOLOGY AND GENETIC ENGINEERING 2023/2024 2022/2023 2021/2022 2020/2021 2019/2020 2018/2019 2017/2018 2016/2017 2015/2016
PROJECT I 2021/2022 2020/2021 2019/2020 2018/2019
SEMINAR 2015/2016 2014/2015
USRAH IN ACTION 1 2023/2024
USRAH IN ACTION 2 2023/2024


Anticancer Activity Of Ionic Liquid Graviola Fruit (Annona Muricata) Extract On Mcf-7 And Ht29 Cancer Cell Lines Using In Vitro And In Vivo Methods.
Ph.D Completed 2020 Co-supervisor
Exploring The Impact Of Plasmodium Falciparum Kelch 13 Protein Mutations On Artemisinin - Based Antimalarial Drug Interactions : A Computational And Protein Interaction Study.
Master Completed 2024 Main Supervisor
Identification Of Potential Inhibitors Of Human Hexokinase Ii For The Development Of Anti-Dengue Therapeutics.
Master Completed 2021 Main Supervisor
Virtual Screening And Enzymatic Inhibition Analysis Of Bacterially Expressed Lactate Dehydrogenase From Plasmodium Knowlesi For Antimalarial Drug Development.
Master Completed 2021 Main Supervisor
Exploring Chitin-Based Compounds As Inhibitors Of Bacterially-Expressed Human Hexokinase Isoform 2 As Potential Dengue Treatment .
Master In Progress Main Supervisor
Structure-Function Study Of Beta-Glucokinase Directed Evolutionary Library For Catalysing Phosphorothioate Bond Formation.
Master In Progress Co-supervisor

Research Projects

2018 - 2023 Collagen-Like Protein from Selected Bacteria as Alternative For Non-Halal Collagen
2017 - 2019 Fractionation and partial purification of active compounds from agarwood branch extract responsible for the cytotoxic/anticancer activity
2016 - 2021 Interrogating Novel Compounds for Improved Anti-dengue Therapies via Inhibition of Host's Glycolytic Pathway
2015 - 2019 Identification of Novel Antimalarial Agents for the Treatment of Knowlesi Malaria via in silico Screening and Enzynmatic Inhibition Analysis
2023 - Present Deciphering the Mechanism of Chitin as a Potent Inhibitor of Human Hexokinase Isoform 2 for Improved Anti-Dengue Therapeutics
2022 - Present Directed Evolution library construction of kinase enzyme for the mediation of phosphorothioate bond formation using Molecular Dynamics and Machine Learning-assisted Fitness Analysis
2022 - Present Elucidating the Inhibitory Effects of Chitin on Human Hexokinase Isoform 2 as a Lead Compound for Dengue Treatment
2021 - Present Identification of potential anti-malarial compounds from natural products using virtual screening and in-vitro inhibition studies for the treatment of malaria
2020 - Present Confirmation, Validation, and Characterization of Antimalarial Drug (Artemisinin) Resistant K13 Selected Genes on Plasmodium Falciparum in Malaysian Isolates
2020 - Present Investigating the Potential Use of an LED-Photodiode Pair as a Flow Velocimetry Imaging Technique for Non-Invasive Measurement of Peritoneal Dialysis Fluid
2006 - Present Bio-Process and Molecular Engineering Research Unit (BPMERU)

Award & Recognition

10 Dec, 2021 Top Researchers with the Highest Number of Joint Publications from 2019-2021 - International Islamic University Malaysia University
30 Mar, 2021 Main Recipient of Best Journal Award for Science, Technology, and Medicine (International Indexed Journal), MAPIM-KPT Awards Ceremony 2019 - Ministry of Higher Education National
21 Sep, 2015 The Travel Grant Award - Biochemical Society UK International



2023 Repurposing natural products against Plasmodium Knowlesi lactate dehydrogenase via in Silico approach for antimalarial drug development. Chemical and Natural Resorces Engineering Journal, 7 (2) pp. 78-87
2022 Analogues of Oxamate, Pyruvate, and Lactate as potential inhibitors of Plasmodium Knowlesi lactate Dehydrogenase identified using virtual screening and verified via Inhibition Assays. Processes, 10 (11) pp. 1-8
2022 Evaluating the binding interactions between Artemisinin and Kelch 13 protein mutants via molecular modelling and docking studies. Journal of Advanced Research in Applied Sciences and Engineering Technology, 28 (3) pp. 272-286
2021 Enhanced expression and purification strategy for recombinant bacterially-expressed human hexokinase II. Molekul, 16 (1) pp. 82-91
2021 Purifying and characterizing bacterially expressed soluble Lactate Dehydrogenase from Plasmodium knowlesi for the development of anti-malarial drugs. Molecules, 26 (21) pp.
2021 Virtual screening for potential inhibitors of human hexokinase II for the development of anti-dengue therapeutics. BioTech, 10 (1) pp. 1-28
2020 Effects of Daidzin and analogue of Ganoderma sinense on bacterially-expressed human hexokinase isoform 2 for anti-dengue drug design. Biological And Natural Resources Engineering Journal, 3 (2) pp. 27-34
2019 Antiproliferative activity of ionic liquid-graviola fruit extract against human breast cancer (MCF-7) cell lines using flow cytometry techniques. Journal of Ethnopharmacology, 236 () pp. 466-473
2019 Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches. Microorganisms, 7 (9) pp. 1-28
2019 Identifying analogues of 2-deoxyglucose, alpha-d-glucose and beta-d-glucose-6-phosphate as potential inhibitors of human hexokinase ii for the development of anti-dengue therapeutics. Pertanika Journal of Science and Technology, 27 (4) pp. 1625-1647
2019 Plasmodial enzymes in metabolic pathways as therapeutic targets and contemporary strategies to discover new antimalarial drugs: a review. Asia-Pacific Journal of Molecular Biology and Biotechnology, 27 (4) pp. 38-53
2017 Screening potential inhibitors of lactate dehydrogenase from Plasmodium knowlesi via virtual screening approaches. Tropical Biomedicine, 34 (4) pp. 1-14
2016 Inhibitors of leishmania mexicana phosphoglycerate mutase identified by virtual screening and verified by inhibition studies. Sains Malaysiana, 45 (7) pp. 1113-1120
2014 Trypanosomatid phosphoglycerate mutases have multiple conformational and oligomeric states. Biochemical and Biophysical Research Communications, 450 () pp. 936-941
2011 Phosphoglycerate mutase from Trypanosoma brucei is hyperactivated by cobalt in vitro, but not in vivo. Metallomics, 3 () pp. 1310-1317
2008 Super binary vector system enhanced transformation frequency and expression level of polyhydroxyvalerate gene in oil palm immature embryo. Asian Journal of Plant Sciences, 7 (6) pp. 526-535
Conference or Workshop Item

2022 The glycolytic pathway is a target for drug discovery against tropical diseases. In: The 4th International Conference on Biosciences & Medical Engineering,
2021 Computational approaches for evaluation of malaria drug resistance in plasmodium species. In: 6th International Conference of Biotechnology Engineering 2021,
2021 Virtual screening and in silico Interactions studies for potential antivirals and diagnostics against the spike protein from the Novel Coronavirus SARS-Cov-2. In: 6th International Conference on Biotechnology Engineering (ICBioE 2021),
2020 Interrogating novel compounds for improved anti-dengue therapies via inhibition of human hexokinase II (HKII). In: Nanotechnology Symposium 2020,
2020 Novel compounds as potential anti-dengue therapies verified via inhibition of human hexokinase isoform II. In: Kulliyyah of Engineering Research, Innovation and Commercialization Exhibition 2020 (KERICE '20),
2019 Elucidating the analogues of 3-bromopyruvate (3-BP) as inhibitors against human hexokinase II for the development of anti-dengue drugs. In: 8th International Molecular Biology And Biotechnology Congress (MOLBIOTECH),
2019 Expression and purification of soluble bacterially-expressed human hexokinase II in E.coli system. In: "9th International Conference on Biomedical Engineering and Technology, ICBET 2019",
2019 In Silico Screening of Inhibitors Against Bacterially Expressed Plasmodium knowlesi Lactate Dehydrogenase Enzyme. In: Kulliiyah of Engineering Research, Innovation, Commercialisation and Exhibition 2019 (KERICE 2019),
2019 Potential inhibitors of Human Hexokinase II for the development of anti-dengue therapeutics identified via in silico approach. In: Kuliyyah of Engineering Research, Innovation and Commercialization Exhibition 2019 (KERICE 2019),
2019 Stimulating scientific minds among early secondary students in Malaysia: a pilot study  using ‘engineering and electronics made fun’ approach. In: 1st International Conference on STEM Education,
2018 Analogues of 2-Deoxyglucose as inhibitor candidates for hexokinase II identified via virtual screening analyses. In: 5th International Conference on Biotechnology Engineering (ICBioE 2018),
2018 Cloning and expression of lactate dehydrogenase from plasmodium knowlesi for anti-malarial drug development. In: Asia Pacific Academic Consortium for Public Health Conference,
2018 Simulation study of bio-methane conversion into hydrogen for generating 500 kw of power. In: 3rd International Conference on Electrical Systems, Technology and Information, ICESTI 2017,
2017 Identifying potential inhibitors of human hexokinase II for the development of anti-dengue therapeutics via virtual screening approaches. In: 4th Asian Regional Conference on Systems Biology,
2016 Cloning and characterisation of Lactate Dehydrogenase Gene from Plasmodium knowlesi in bacterial system. In: Borneo Biotech Symposium,
2016 Potential inhibitors of the glycolytic enzymes from Plasmodium knowlesi identified by virtual screening analysis. In: International Conference of Biotechnology Engineering (ICBioE2016),
2015 Potential novel inhibitors of trypanosomatid phosphoglycerate mutases through ligand-based and structure-based in silico approaches. In: Singapore Health and Biomedical Congress 2015,
2013 Multiple oligomeric and conformational states of trypanosomatid phosphoglycerate mutases. In: 18th Lorne Proteomics Symposium 2013,
Book Section

2018 Characterization of conformational and oligomeric states of proteins. In: Springer Nature Singapore, ISBN: 978-981-13-2256-3, pp. 167-178
2018 Characterization of conformational and oligomeric states of proteins. In: Springer Nature Singapore, ISBN: 978-981-13-2256-3, pp. 167-178
2018 Secondary metabolite research in Malaysia: current status and future prospects. In: IntechOpen, ISBN: 978-1-78923-643-9, pp. 101-111