Staff Directory


Kamal Rullah

Academic Qualification

  • Doctor of Philosophy (Pharmacy) - Doctor of Philosophy, National University of Malaysia
  • M.Sc - Masters Degree, Universitas Riau
  • B.Pharm - Bachelor Degree, Sekolah Tinggi Ilmu Farmasi Riau

Kamal Rullah (Dr.)

Assistant Professor
IIUM Kuantan Campus

KULLIYYAH OF PHARMACY

Other's position:

Head, Kulliyyah of Pharmacy


kamalrullah@iium.edu.my
4934


Expert Profile


Dr. Kamal Rullah obtained B.Pharm in 2007 from the Sekolah Tinggi Ilmu Farmasi Riau,  Apothecary (2008) from the Universitas Andalas and M.Sc (2011) from the Universitas Riau, Indonesia. Since 2008, he was appointed as a Lecturer in Sekolah Tinggi Ilmu Farmasi Riau, Indonesia. He earned his Ph.D Medicinal Chemistry in 2017 from Faculty of Pharmacy, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur and during 2017-2019 he performed postdoctoral research fellow at the Nanotechnology and Catalysis Research Centre (NANOCAT) University of Malaya (UM), working on organic synthesis sulphur-based compound collaboration with leading R&D Europe companies. He joined the academic member at Kulliyah of Pharmacy (KOP), International Islamic University Malaysia (IIUM) in 2019. His research interests are design and synthesis of new-bioactive molecule for application in chemical biology and precious medicine.    



Area of Specialisation


  • Medical And Health ~ Medical And Health Sciences ~ Pharmacy ~ Medicinal Chemistry 84 - Drug Discovery and Drug Design Development
  • Natural Science ~ Chemical Sciences ~ Organic Chemistry ~ Medicinal Chemistry - Drug Synthesis


Teaching Responsibilities


ANTI-INFECTIVE AGENTS 2023/2024 2022/2023 2021/2022 2020/2021
BODY SYSTEM & THERAPEUTICS III: MSK SYSTEM & SENSORY ORGANS 2023/2024 2022/2023 2021/2022
BODY SYSTEM III : MUSCULOSKELETAL & SENSORY ORGANS 2019/2020
COMPUTER AIDED DRUG DESIGN AND DISCOVERY 2019/2020
COMPUTER-AIDED DRUG DESIGN AND DISCOVERY 2023/2024 2022/2023 2021/2022 2020/2021
FINAL YEAR RESEARCH PROJECT 2023/2024 2022/2023
FUNDAMENTALS OF MEDICINAL CHEMISTRY 2023/2024 2022/2023 2021/2022 2020/2021 2019/2020
HERBAL MEDICINE 2020/2021 2019/2020
NUCLEAR PHARMACY 2023/2024 2022/2023 2020/2021
PHARMACEUTICAL INSTRUMENTAL ANALYSIS 2023/2024 2022/2023 2021/2022 2020/2021
PHARMACEUTICAL ORGANIC CHEMISTRY 2019/2020
RESEARCH PROJECT 1 2021/2022
RESEARCH PROJECT-LITERATURE SEARCH 2020/2021


Supervision


Synthesis And Computer-Aided Analysis Of Novel Chromone-Based Kr-1401-Kw Derivatives N-Heterocycles As Anti-Inflammatory And Anti-Cancer Agents.
Ph.D In Progress Main Supervisor
Design, Synthesis And Biological Activity Of Functionalized Kr-2001-Kw Chromone-Based As Potential Anticancer And Anti-Inflammatory Agents.
Ph.D In Progress Main Supervisor


Research Projects


Completed
2021 - 2024 Encapsulation of Malaysian Patin Oil-loaded Alginate Microbeads Prototype for Supporting Children's Growth
2020 - 2023 Pharmacological Evaluation of a novel chloro-containing flavonoid molecule (KR-2001-KW) as an anticancer agent
2019 - 2022 Development and characterization of nanofibers patch containing nicotine using electrospinning: a novel approach as nicotine replacement therapy.
On-Going
2022 - Present Synthesis and Computer-Aided Analysis of Novel Chromone-Based KR-1401-KW Derivatives as COX-2/PGE2 Suppressor Against Cancer-prone Chronic Inflammatory Diseases


Award & Recognition


11 Nov, 2022 The Most Creative/Innovative Lecturer Award 2022 - Kulliyyah of Pharmacy (KOP) KCDIO
22 Feb, 2022 Top 3 Academic Staff with The Most Grant & Consultancy recipient in year 2020 (KOP Takrim Day 2021) - Kulliyyah of Pharmacy (KOP) KCDIO
21 Oct, 2021 The Most Creative & Creative Lecturer 2021 - Kulliyyah of Pharmacy (KOP) KCDIO
05 Feb, 2020 Reviewing award February 2020: Journal of Molecular Structure. - Elsevier Publisher International
07 Mar, 2018 Chairman - International Congress on Pure & Applied Chemistry (ICPAC 2018)-Cambodia International
19 Mar, 2014 The Best Poster Presentation - International Conference Natural Product (ICNP) 2014-Malaysia Natural Product Society (MNPS) International


Publications


Article

2024 Nicotine-loaded polyvinyl alcohol electrospun nanofibers as transdermal patches for smoking cessation: formulation and characterization. Pharmaceutical Chemistry Journal, 57 (10) pp. 1637-1646
2023 Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches. Molecular Biotechnology, () pp. 1-11
2023 Insight parameter drug design for human β-tryptase inhibition integrated molecular docking, QSAR, molecular dynamics simulation, and pharmacophore modelling studies of α-keto-[1,2,4]-oxadiazoles. Journal of Biomolecular Structure and Dynamics, () pp.
2023 Pharmacophore-based molecular docking of usnic acid derivatives to discover anti-viral drugs against influenza A virus. Journal of Research in Pharmacy, 27 (3) pp. 1021-1038
2023 Synthesis of dihydropyrimidinone (DHPM) derivatives through a multicomponent reaction (MCR) and their biological activity. Journal of Medicinal and Chemical Sciences, 6 (8) pp. 1810-1817
2023 Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation. Journal of Biomolecular Structure and Dynamics, 41 (23) pp. 13632-13645
2022 A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer. Journal of Computational Biophysics and Chemistry, 21 (6) pp. 611-627
2022 Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses. Journal of Computational Biophysics and Chemistry, () pp. 1-21
2021 Biomedical application of responsive ‘smart’ electrospun nanofibers in drug delivery system: a minireview. Arabian Journal of Chemistry, 14 (7) pp.
2021 Virtual screening-based identification of potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database. Journal of Computational Biophysics and Chemistry, 20 (8) pp. 797-814
2020 Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies. Bioorganic Chemistry, 94 () pp. 1-12
2020 Targeted delivery of 5-fluorouracil-1-acetic acid (5-FA) to cancer cells overexpressing epithelial growth factor receptor (EGFR) using virus-like nanoparticles. Scientific Reports, 10 (1) pp.
2019 Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA. Journal of Molecular Structure, 1196 () pp. 844-850
2019 Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183 () pp.
2019 Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway. Chemical Biology and Drug Design, 93 (3) pp. 1-10
2019 Palladium‐catalysed cross‐coupling reactions for the synthesis of chalcones. Asian Journal of Organic Chemistry, 8 (8) pp. 1174-1193
2018 Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment. Molecules, 23 (10) pp. 1-19
2018 Kajian dok molekul mengenai interaksi antara RNA-bergantung RNA polimerase virus denggi dan analog nukleosida = Molecular docking study of the interactions between dengue virus RNA-dependent-RNA polymerase and nucleoside analogues. Sains Malaysiana, 47 (3) pp. 517-522
2018 Synthesis, biological evaluation and docking studies of aurone derivatives on Xanthine oxidase enzyme. Jurnal Sains Kesihatan Malaysia (JSKM), 16 (1) pp. 135-143
2017 Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives. Medicinal Chemistry Research, 26 (12) pp. 3323-3335
2016 Effects of tocotrienols on insulin secretion-associated genes expression of rat pancreatic islets in a dynamic culture. Frontiers in Pharmacology, 7 () pp. 1-17
2016 Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells. RSC Advances, 6 (76) pp. 72177-72184
2016 Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorganic & Medicinal Chemistry Letters, 26 (10) pp. 2531-2538
2015 Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor. Journal of Molecular Structure, 1081 () pp. 51-61
2015 Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. Bioorganic & Medicinal Chemistry Letters, 25 (16) pp. 3330-3337
2015 Probing the effects of fish oil on the delivery and inflammation-inducing potential of imiquimod. International Journal of Pharmaceutics, 490 () pp. 131-141
2015 Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors. Medicinal Chemistry Communication, 6 () pp. 1069-1080
2014 Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation. Bioorganic & Medicinal Chemistry Letters, 24 (16) pp. 3826-3834
2014 Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor. Molecules, 19 (8) pp. 11645-11659
2014 Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents. Molecules, 19 (10) pp. 16058-16081
Conference or Workshop Item

2022 A promising chromone-based compounds in drug discovery for new anti-inflammatory and anti-cancer drugs. In: International Conference on Contemporary Science and Clinical Pharmacy (ICCSCP) 2022,
2022 Extraction of fish oil by using wet rendering from Patin fish (Pangasianodon Hypophthalmus). In: International Conference on Pharmaceutical Sciences ICOPS@IIUM2022,
2022 Synthesis of flavone-based compounds as ros-dependent apoptosis inducers in colorectal cancer. In: International Conference on Pharmaceutical Sciences ICOPS@IIUM2022, 08-09 August 2022, IIUM, Kuantan.,
2021 In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking. In: 2nd Postgraduate Symposium on Industrial Science and Technology, SISTEC 2020,
2021 In silico functional and structural insight of prenylated pyrazolocurcumin derivative associated with the PGE2 inhibition through mPGES-1 blocking. In: 2nd Postgraduate Symposium on Industrial Science and Technology, SISTEC 2020,
2019 Synthesis and SAR studies of new chromone derivatives as Inhibitors of PGE2 production. In: 1st Malaysian Association for Cancer Research (MACR) Scientific Conference (1st MSC) 2019,
Book Section

2020 Synthesis, In silico molecular docking modeling and pharmacophore mapping of (E)-3-(4-hydroxy-2,6-dimethoxyphenyl)-1-phenylprop-2-en-1- one as potential new inhibitor of microsomal prostaglandin E synthase-1. In: Trans Tech Publications Ltd, ISBN: 978-303571664-1, pp. 247-252